Comparison of PET/CT vs. PET/MRI Using 2 Radiopharmaceuticals

Phase 2

Completed

Conditions: Diagnostic Techniques and Procedures
Diagnostic Imaging
Cancer Diagnosis

Interventions: Drug: F-18 FDG
Drug: Ga-68-DOTA-TATE
Device: Positron Emission Tomography / Computed Tomography (PET/CT) Scan
Device: Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) Scan

Brief Summary: This clinical trial studies how well positron emission tomography (PET)/computed tomography (CT) works compared to PET/magnetic resonance imaging (MRI) in evaluating patients with cancer. PET/CT and PET/MRI may determine which scanner is best for the patient's type of cancer and other types of cancers.

Detailed Description: PRIMARY OBJECTIVES:

I. To evaluate if PET/CT and PET/MRI scanners provide equivalent results for evaluation of cancer patients.

OUTLINE:

Patients receive standard of care 18F-fludeoxyglucose (FDG) or Ga68-DOTA-TATE intravenously (IV). Within 45-60 minutes, patients then undergo PET/CT imaging immediately followed by PET/MRI. Each participant is to receive 18-FDG or 68Ga-DOTA-TATE only, no participant was to receive both radiotracers.

Recruitment & Eligibility

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Arm && Interventions

Group	Intervention	Description
18F-FDG PET/CT Scan	F-18 FDG	Participants will undergo a PET/CT scan with radiolabel 18F-FDG.
18F-FDG PET/CT Scan	Positron Emission Tomography / Computed Tomography (PET/CT) Scan	Participants will undergo a PET/CT scan with radiolabel 18F-FDG.
18F-FDG PET/MRI Scan	F-18 FDG	Participants will undergo a PET/MRI scan with radiolabel 18F-FDG.
18F-FDG PET/MRI Scan	Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) Scan	Participants will undergo a PET/MRI scan with radiolabel 18F-FDG.
68Ga-DOTA-TATE PET/CT Scan	Ga-68-DOTA-TATE	Participants will undergo a PET/CT scan with radiolabel 68Ga-DOTA-TATE.
68Ga-DOTA-TATE PET/CT Scan	Positron Emission Tomography / Computed Tomography (PET/CT) Scan	Participants will undergo a PET/CT scan with radiolabel 68Ga-DOTA-TATE.
68Ga-DOTA-TATE PET/MRI Scan	Ga-68-DOTA-TATE	Participants will undergo a PET/MRI scan with radiolabel 68Ga-DOTA-TATE.
68Ga-DOTA-TATE PET/MRI Scan	Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) Scan	Participants will undergo a PET/MRI scan with radiolabel 68Ga-DOTA-TATE.

Primary Outcome Measures

Name	Time	Method
Absolute Accuracy of SUV Max of PET/CT vs PET/MRI	4 hours	Standardized uptake value max (SUVmax) is a measurement of the maximum radiopharmaceutical uptake value within the region of interest (ROI). SUVmax is calculated as the ratio of activity concentration:injected dose/body weight. The outcome is reported as the mean SUVmax with standard deviation (SD), reported for 8 specific organs or bodily locations.

Secondary Outcome Measures

Name	Time	Method
PET/CT vs PET/MRI Difference in Standardized Uptake Value Max (SUVmax), by Radiotracer	estimated average of 2 hours	Standardized uptake value max (SUVmax) is a measurement of the maximum radiopharmaceutical uptake within the region of interest (ROI). Relative accuracy of a particular radiotracer in a particular tissue is determined by expressing the absolute accuracy (obtained in the primary outcome measure) in terms of percent difference between SUVmax values obtained from PET/CT and PET/MR. Percentage difference is expressed as the difference of the means in SUVmax for the PET/CT and PET/MRI scan procedures for the particular radiotracer, divided by the mean between the values for the 2 scan procedures. The closer the percent difference is to 0%, the better the agreement between the two scanners. The outcome is expressed as the percentage difference, a number without dispersion.