Comparison of PET/CT vs. PET/MRI
Overview
- Phase
- Phase 2
- Intervention
- F-18 FDG
- Conditions
- Cancer Diagnosis
- Sponsor
- Stanford University
- Enrollment
- 53
- Locations
- 1
- Primary Endpoint
- Absolute Accuracy of SUV Max of PET/CT vs PET/MRI
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This clinical trial studies how well positron emission tomography (PET)/computed tomography (CT) works compared to PET/magnetic resonance imaging (MRI) in evaluating patients with cancer. PET/CT and PET/MRI may determine which scanner is best for the patient's type of cancer and other types of cancers.
Detailed Description
PRIMARY OBJECTIVES: I. To evaluate if PET/CT and PET/MRI scanners provide equivalent results for evaluation of cancer patients. OUTLINE: Patients receive standard of care 18F-fludeoxyglucose (FDG) or Ga68-DOTA-TATE intravenously (IV). Within 45-60 minutes, patients then undergo PET/CT imaging immediately followed by PET/MRI. Each participant is to receive 18-FDG or 68Ga-DOTA-TATE only, no participant was to receive both radiotracers.
Investigators
Andrei Iagaru
Associate Professor of Radiology
Stanford University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
18F-FDG PET/MRI Scan
Participants will undergo a PET/MRI scan with radiolabel 18F-FDG.
Intervention: F-18 FDG
18F-FDG PET/CT Scan
Participants will undergo a PET/CT scan with radiolabel 18F-FDG.
Intervention: F-18 FDG
18F-FDG PET/CT Scan
Participants will undergo a PET/CT scan with radiolabel 18F-FDG.
Intervention: Positron Emission Tomography / Computed Tomography (PET/CT) Scan
18F-FDG PET/MRI Scan
Participants will undergo a PET/MRI scan with radiolabel 18F-FDG.
Intervention: Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) Scan
68Ga-DOTA-TATE PET/CT Scan
Participants will undergo a PET/CT scan with radiolabel 68Ga-DOTA-TATE.
Intervention: Ga-68-DOTA-TATE
68Ga-DOTA-TATE PET/CT Scan
Participants will undergo a PET/CT scan with radiolabel 68Ga-DOTA-TATE.
Intervention: Positron Emission Tomography / Computed Tomography (PET/CT) Scan
68Ga-DOTA-TATE PET/MRI Scan
Participants will undergo a PET/MRI scan with radiolabel 68Ga-DOTA-TATE.
Intervention: Ga-68-DOTA-TATE
68Ga-DOTA-TATE PET/MRI Scan
Participants will undergo a PET/MRI scan with radiolabel 68Ga-DOTA-TATE.
Intervention: Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) Scan
Outcomes
Primary Outcomes
Absolute Accuracy of SUV Max of PET/CT vs PET/MRI
Time Frame: 4 hours
Standardized uptake value max (SUVmax) is a measurement of the maximum radiopharmaceutical uptake value within the region of interest (ROI). SUVmax is calculated as the ratio of activity concentration:injected dose/body weight. The outcome is reported as the mean SUVmax with standard deviation (SD), reported for 8 specific organs or bodily locations.
Secondary Outcomes
- PET/CT vs PET/MRI Difference in Standardized Uptake Value Max (SUVmax), by Radiotracer(estimated average of 2 hours)