A study of the mechanics of breathlessness and how these change following drainage of a pleural effusio

Not Applicable

Completed

• Conditions: Pleural effusion; Respiratory

• Registration Number: ISRCTN36677860
• Lead Sponsor: Guy's And St Thomas' NHS Foundation Trust

Brief Summary

2021 Abstract results in https://dx.doi.org/10.1183/13993003.congress-2021.OA1519 This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”. (added 15/11/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-03
• Study Completion: 2020-09-16
• Last Update Posted: 28 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

1. Unilateral pleural effusion requiring thoracentesis on clinical grounds
2. Aged 18 years and over

Exclusion Criteria

1. Age less than 18 years old
2. Any contraindications to thoracocentesis
3. Evidence of loculation on ultrasound
4. Unable to undergo procedure comfortably for up to one hour
5. Allergy to lidocaine
6. Unable to tolerate oesophageal catheter placement
7. Suspected trapped lung based on clinical suspicion
8. Pre-existing lung disease
9. Any previous pleural intervention on ipsilateral side excluding previous thoracocentesis
10. Past medical history of diaphragmatic paralysis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eural respiratory drive is measured by diaphragmatic EMG at baseline, continuously during thoracocentesis and up to 10 minutes post procedure.

Secondary Outcome Measures

Name	Time	Method
1. Diaphragmatic excursion is measured by M-mode ultrasonography at baseline and every 250mls to the end of thoracocentesis procedure<br>2. Pleural pressure is measured using pleural manometry at baseline and every 250mls to the end of thoracocentesis procedure<br>3. Change in breathlessness measured by the Multidimensional Dyspnea Profile and 100mm visual analogue scale (VAS) at baseline, 1 hour post thoracentesis and 24 hours post-thoracentesis<br>4. Exercise tolerance measured using the 6 minute walk test at baseline and 24 hours post-thoracocentesis