Characterization of the incretin response and microbiota following bariatric surgery, and its role for weight loss – a search for polytherapeutic strategies to combat obesity and ultimately rival surgery
Not Applicable
Recruiting
- Conditions
- ObesityNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN11764561
- Lead Sponsor
- Södertälje Sjukhus
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
1. Obese non-diabetic females
2. 18-65 years of age
3. Signed informed consent form
Exclusion Criteria
1. Type 2 diabetes
2. Any history of receiving GLP-1 analogues or DPP-4 inhibitors
3. Previous treatment with insulin (any regimen) within 3 months
4. Current or history of drug and alcohol abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Plasma GLP-1, measured using the meal tolerance test and GLP-1 specific ELISA of serum samples<br> 2. Gut microbiota composition, analyzed from fecal samples<br> Timepoints: before 10-day diet, after 10-day diet/before surgery, 3 months after surgery, 6 months after surgery<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Plasma inflammatory markers, analyzed by specific ELISAs<br> 2. Lipid profile, determined by commercially available HDL and LDL/VLDL Cholesterol Assay Kits, Free Fatty Acid Quantification Kit, as well as Triglyceride Quantification Kit<br><br> Timepoints: before 10-day diet, after 10-day diet/before surgery, 3 months after surgery, 6 months after surgery<br>