Evaluation of intestinal hormones in healthy patients and in obese patients with and without type 2 diabetes through isoglycemic clamp before and after stomach reduction surgery
- Conditions
- Type 2 diabetes, obesity, bariatric surgery.
- Registration Number
- RBR-5vsmm6
- Lead Sponsor
- niversidade Estadual de Campinas
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Age between 30 and 60 years, type 2 diabetic patients without medication for diabetes or who are not making use for at least 3 months; weight variation of less than 5% in the last three months; ability to understand the study procedures and voluntarily agree to participate in the study and signed an informed consent form.
Age under 30 and over 60, patients with type 2 diabetes using insulin, type 2 diabetics with poorly controlled diabetes (glycated hemoglobin A1c greater than 8.5%), BMI less than 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; changing functions renal function (creatinine greater than 1.4 mg / dl in women and greater than 1.5 mg / dl in men) and hepatic ALT and / or AST 3 times above normal; recent history of malignancy (less than 5 years), use of injectable or oral steroids for more than 14 consecutive days in the past 3 months, or with some drug side effects on glucose metabolism.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the incretin effect evaluated by isoglycemic clamp technique in healthy, obese subjects with normal glucose tolerance and type 2 diabetic obese.;No statistical difference was found between the incretin effect of different groups.
- Secondary Outcome Measures
Name Time Method Evaluation of the incretin profile evolution by isoglycemic clamp technique in the group of obese diabetic patients 1 and 12 months after surgery by the technique of biliopancreatic diversion.;Improvement on incretin effect one year after biliopancreatic diversion surgery assessed by isoglycemic clamp test.