Physiological Effects of Creatine Supplementation in Active Males
- Conditions
- Dietary Supplementation
- Interventions
- Dietary Supplement: Creatine monohydrateDietary Supplement: PlaceboDietary Supplement: Creatine nitrate
- Registration Number
- NCT03003988
- Lead Sponsor
- Texas A&M University
- Brief Summary
This study was designed to examine how different forms of creatine impact active males.
- Detailed Description
This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 48
- participants are apparently healthy and recreationally active males between the ages of 18 and 40;
- participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;
- participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease;
- participants are currently using prescription medications;
- participants have a history of smoking;
- participants drink excessively (i.e., 12 drinks per week or more);
- participants have a recent history of creatine supplementation within six weeks of the start of supplementation;
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Creatine monohydrate Creatine monohydrate Creatine monohydrate (6.0 g.) + dextrose (0.5 g.) Placebo Placebo 6.5 g. dextrose Creatine nitrate Creatine nitrate Creatine nitrate (5.0 g. creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio).
- Primary Outcome Measures
Name Time Method Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water 28 Days Assessing Body Water through Bioelectrical Impedance Analysis (BIA)
Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular creatine 28 Days Assessing intramuscular creatine using standard spectrophotometric methods using a microplate spectrophotometer
Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular ATP 28 Days Assessing intramuscular Adenosine Triphosphate (ATP) using standard spectrophotometric methods using a microplate spectrophotometer
Effects of 28 Days of Different Forms of Creatine Supplementation on Body Composition 28 Days Assessing Body Compositing through Dual-Energy X-Ray Absorptiometry (DXA)
Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular phosphocreatine 28 Days Assessing intramuscular phosphocreatine using standard spectrophotometric methods using a microplate spectrophotometer
Effects of 28 Days of Different Forms of Creatine Supplementation on anaerobic capacity 28 Days Assessing anaerobic capacity through 6 x 6 second sprints followed by a 30 second sprint on a Wingate bicycle ergometer
Effects of 28 Days of Different Forms of Creatine Supplementation on muscular strength 28 Days Assessing muscular strength through 1 Repetition Maximum (RM) testing
Effects of 28 Days of Different Forms of Creatine Supplementation on muscular endurance 28 Days Assessing muscular endurance through repetition to failure testing
- Secondary Outcome Measures
Name Time Method Effects of 28 Days of Different Forms of Creatine Supplementation on blood 28 Days Measure standard clinical chemistry panels in the blood to evaluate safety
Effects of 28 Days of Different Forms of Creatine Supplementation on training volume (weight lifted x number of repetitions x number of sets) 28 Days Assessing training volume using a calculator
Effects of 28 Days of Different Forms of Creatine Supplementation on self-reported side effects 28 Days Assessing self-reported side effects using a side effects questionnaire