NCT01042210已完成不适用
Genotype-phenotype Associations of Agouti-related Peptide (AgRP) in Postpartum Period in Preeclamptic and Non-preeclamptic Women and Their Offspring
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- plasma/serum level of agouti/related peptide in peripheral blood in postpartum mother
研究概览
简要总结
The study is focused on the investigation of possible associations between plasma/serum levels of agouti related peptide (AgRP) and its genetic background in healthy women with physiological pregnancy (non-preeclamptic) and women with preeclampsia, in the postpartum period, and in their offspring.
详细描述
The study is focused on investigation of possible genotype-phenotype interactions of agouti-related peptide (AgRP) in postpartum non-preeclamptic women and preeclamptic women and in their offspring.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •For preeclampsia:
- •development of hypertension after the 20th week of pregnancy (systolic blood pressure, ≥140 mmHg; and/or diastolic blood pressure, ≥90 mmHg; measured at rest on two consecutive occasions at least 24 h apart) in previously normotensive women, and the onset of proteinuria (>300 mg of urinary protein/L over 24 h)
- •single-fetus pregnancy
- •age range 18-35 y
- •no preconceptional history of hypertension
- •For mother with physiological pregnancies:
- •uncomplicated
- •spontaneous conception
- •single-fetus pregnancy
- •age range 18-35 y
- •spontaneous uncomplicated delivery
- •no history of preconceptional hypertension
排除标准
- •For preeclampsia:
- •multiple pregnancy
- •preeclampsia superimposed to chronic hypertension preceding pregnancy
- •kidney disease
- •fetal malformations
- •For mothers with physiological pregnancies:
- •in vitro fertilization
- •fetal malformations
- •multiple pregnancy
- •events of bleeding
结局指标
主要结局
plasma/serum level of agouti/related peptide in peripheral blood in postpartum mother
时间窗: 2-4 hours postpartum
Plasma level of agouti-related peptide in umbilical cord blood from the newborn
时间窗: immediately postpartum
次要结局
- maternal weight gain during pregnancy(using postpartum and peripartum data)
- birth weight of the newborn(immediately postpartum)
- maternal preconceptional BMI(anamnestic information)
研究者
研究点 (1)
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