NCT01232244已完成不适用
Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
University Hospital, Gentofte, Copenhagen1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2010年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Hunger
研究概览
简要总结
Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss.
Therefore we want to investigate mechanistic relations between the three hormones.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Normal fasting plasma glucose
- •Normal glucose tolerance
- •Normal haemoglobin levels
- •Informed content
排除标准
- •Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
- •1st degree relatives with diabetes
- •Obesity (BMI > 30)
- •Inflammatory bowels disease
- •Bowels surgery
- •Nephropathy
- •Liver disease
- •Medication which cannot be on hold for 24h
结局指标
主要结局
Hunger
时间窗: 4 h
Assessed by an ad'libitum meal
Satiety
时间窗: 4 h
Assessed by VAS
basal energy expenditure
时间窗: 2 x 30min
Assessed by indirect calorimetry
Gastric emptying
时间窗: 4 h
Assessed by the acetaminophen - method
次要结局
- Oxyntomodulin(4 h)
- Glucagon(4 h)
- GIP(4 h)
- GLP-1(4 h)
研究者
Jonatan I Bagger
MD
University Hospital, Gentofte, Copenhagen
研究点 (1)
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