The Effects of Dexmedetomidine on Cerebral Autoregulation and Cerebral Oxygenation in Subarachnoid Haemorrhage Patients
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Change in autoregulation, ICP and cerebral oxygenation
研究概览
简要总结
The purpose of this study is to investigate how dexmedetomidine affects static and dynamic autoregulation, intracranial pressure (ICP) and cerebral oxygenation in aneurysmal subarachnoid haemorrhage (SAH) patients.
详细描述
Dexmedetomidine is a selective α2-agonist which induces sedation, anxiolysis and analgesia without respiratory depression. These effects, as well as neuroprotective properties in experimental studies would be ideal in neuroanaesthesia and in neurocritical care. Poor grade SAH patients are treated in intensive care units (ICU). These patients are sedated often with propofol. However, to assess the patient's neurology, the propofol sedation must be stopped and the wakening of the patient may take time. Dexmedetomidine would be more advantageous, allowing wakening during the infusion. However, the effects of dexmedetomidine on cerebral autoregulation are unknown in SAH patients.
15 SAH patients requiring sedation, mechanical ventilation and ICP monitoring will be rolled in to the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aneurysmal SAH
- •Aneurysm treated with coil(s) or clip(s)
- •Age 18-80 years
- •Written informed consent from the next of kin
排除标准
- •Pregnancy
- •Nursing woman
- •Sick sinus syndrome
- •Carotid stenosis
- •Heart rate less than 50 beats / minute
- •Mean arterial pressure less than 50 mmHg
研究组 & 干预措施
Dexmedetomine infusion
干预措施: Dexmedetomidine infusion (Drug)
结局指标
主要结局
Change in autoregulation, ICP and cerebral oxygenation
时间窗: 2, 4 and 6 hours
Autoregulation is assessed using transcranial doppler (TCD) and ICP amplitude analysis. ICP and cerebral oxygenation are part of standard multimodal monitoring and these are continuously monitored and recorded.
次要结局
未报告次要终点
研究者
Riikka Takala
MD, PhD Senior Staff Anaesthesiologist
Turku University Hospital