Effect of dexmedetomidine on cerebral autoregulation during general anaesthesia
Phase 3
Completed
- Conditions
- Health Condition 1: null- ASA I, UNDERGOING LUMBAR LAMINECTOMY WITH NO INTRACRANIAL PATHOLOGY
- Registration Number
- CTRI/2015/06/005875
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
adults aged 18-60 years who present for lumbosacral spine surgery.
Exclusion Criteria
1.Refusal of consent
2.Pregnancy
3.Morbid obesity
4.Patients with comorbidities, ASA II and above , including cardiac rhythm abnormalities
5.Addictions(smoking/regular alcohol intake/IV drug abuse)
6.Drug intake(OCPs/SSRIs/TCAs/anticonvulsants/statins etc.)
7.Carotid disease/history of syncope/dizziness
8.Hyperlipidemia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.to study the effect of dexmedetomidine as an anaesthetic adjuvant on cerebral autoregulation and CO2 reactivity using transcranial dopplerTimepoint: 5 mins after induction of anesthesia when BIS stable between 40-50.
- Secondary Outcome Measures
Name Time Method 1.effect of dexmedetomidine on intraoperative haemodynamic parameters during various stages of anaesthesia <br/ ><br>2.anaesthetic agent consumption <br/ ><br>3.time to recovery, extubation and quality of emergence <br/ ><br>4.side effects and complications noted with the technique <br/ ><br>Timepoint: intraoperative <br/ ><br>postoperative