The neuro-behavioural effects of Dexmedetomidine Vs Morphine in adult patients after cardiac surgery

Recruiting

• Conditions: Delirium post cardiac surgery; Cardiovascular - Other surgery; Neurological - Other neurological disorders

• Registration Number: ACTRN12606000084583
• Lead Sponsor: Prince of Wales Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-03-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Patients undergoing cardiac surgery on bypass including CABG, valve surgery, combination CABG and/or valve replacement procedures.·Patients who have given consent.

Exclusion Criteria

Allergy to any of the trial drugs.·Creatinine >134 mmol/L or creatinine clearance calculated by Cockcroft Gault formula of <50ml/min·Receiving other alpha 2 agonists like Clonidine.·Patients on psychotic drugs other than night time hypnotics.·Pre operative dementia/ Parkinsonism/ Other cerebral illness.·Non English speaking patients.·Weight greater than 150 Kgs.·Surgery involving intracranial vasculature within last 3 months·Surgery involving free flap within last 3 months ·Receiving neuromuscular blockers for reasons other than performing endotracheal intubation.·Patients receiving regional analgesia·Haemodynamic instability, i.e. HR < 55 beats per minute, Systolic blood pressure < 90 mmHg.·Failure to obtain consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified