Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Not Applicable
Completed
- Conditions
- Chronic Obstructive Pulmonary Disease
- Registration Number
- NCT01042080
- Lead Sponsor
- Hôpital Européen Marseille
- Brief Summary
NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway. The investigators hypothesized that NAVA improved patient-ventilator synchrony and reduced inspiratory workload as compared with pressure support ventilation delivered at two different cycling criteria (25 and 50 %).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- History of chronic obstructive pulmonary disease
- Admitted for acute respiratory failure requiring invasive mechanical ventilation
- Currently receiving pressure support ventilation
Exclusion Criteria
- Age < 18 years
- Respiratory rate > 35 bpm
- Severe hypoxemia with SpO2 < 88 % and FIO2 > 50 %
- Heart rate > 120 bpm
- Systolic arterial pressure < 90 mmHg
- Contraindication to naso-gastric tube's insertion
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Inspiratory muscle workload as reflected by the diaphragmatic Pressure Time Product (PTPdi) 5 minutes
- Secondary Outcome Measures
Name Time Method Arterial blood gases 20 minutes Trigger delay 5 minutes Ineffective inspiratory effort 5 minutes Dynamic intrinsic PEEP 5 minutes
Trial Locations
- Locations (2)
Hopital Paul Desbief
🇫🇷Marseille, France
Fondation Hôpital Ambroise Paré
🇫🇷Marseille, France
Hopital Paul Desbief🇫🇷Marseille, France