The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

• Conditions: Telomere Length; Mechanisms of Telomter Homeostasis; High Risk Pregnancies

• Registration Number: NCT01384136
• Lead Sponsor: Meir Medical Center

Brief Summary

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-06
• Study Start: 2011-06
• Study First Submitted: 2011-06-27
• Study First Submitted QC: 2011-06-27
• Last Update Submitted: 2011-06-27
• Study First Posted: 2011-06-28
• Last Update Posted: 2011-06-28
• Primary Completion: 2015-06
• Study Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Third trimester post delivery
• Intrauterine growth restriction
• Preeclampsia
• Diabetes
• Control - low risk normal pregnancies

Exclusion Criteria

• Patients who do not want to participate
• Known HIV or Hepatitis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar Saba, Israel