Association Between Telomere Length and Cardiac Dysfunction

Completed

• Conditions: Childhood Cancer; Acute Leukemia; Cardiac Toxicity
• Interventions: Diagnostic Test: Relative telomere length

• Registration Number: NCT04409379
• Lead Sponsor: Air Force Military Medical University, China

Brief Summary

Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-01
• Status Verified: 2020-05
• Primary Completion: 2020-05-01
• Study Completion: 2020-05-01
• Study First Submitted: 2020-05-27
• Study First Submitted QC: 2020-05-27
• Last Update Submitted: 2020-05-27
• Study First Posted: 2020-06-01
• Last Update Posted: 2020-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• 1. histological confirmed acute leukemia; 2. Preparing for chemotherapy;

Exclusion Criteria

• 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
acute leukemia group	Relative telomere length	300 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy

Primary Outcome Measures

Name	Time	Method
Relative telomere length	From date of admission until the date of discharging from hospital, assessed up to 5 days	The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL.

Trial Locations

Locations (1)

Xiao-Fan Zhu; 🇨🇳 Tianjin, Tianjin, China