Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Corneal staining score change from baseline at 2 months
研究概览
简要总结
Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Osteoarthritis with
- •Ocular surface index score ≥ 13 with
- •Corneal staining score ≥ 3
排除标准
- •Allergic to diacerein
- •Use Cyclosporin within 30 days
- •Eyelid problem
- •Change artificial tear while in the study
- •Pregnancy or breast feeding
研究组 & 干预措施
Diacerein group
Osteoarthritis and dry eye patients treated with Diacerein
干预措施: Diacerein (Drug)
结局指标
主要结局
Corneal staining score change from baseline at 2 months
时间窗: At the time of enrollment and 2 months
Stain Cornea with Fluorescine, count and score staining at the cornea according to National eye institute : score 0-15 (0=no staining)
次要结局
- Ocular surface disease index score(At the time of enrollment and 2 months)
- Tear Osmolarity(At the time of enrollment and 2 months)
- Interleukin-1 receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear(At the time of enrollment and 2 months)
- Tear break up time(At the time of enrollment and 2 months)
- Schirmer 1 test(At the time of enrollment and 2 months)
研究者
Ngamjit Kasetsuwan
Associate professor
Chulalongkorn University