comparing the therapeutic effects of intranasal, intramuscular, intravenous B12 administration on haematological parameters in B12 deficiency anaemia
Overview
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Armed Forces Medical College
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- COMPARE THE CHANGE IN HEMATOLOGICAL PARAMETERS (HAEMOGLOBIN, MEAN CORPUSCULAR VOLUME)
Overview
Brief Summary
A total of 100 patients will be enrolled in the study. These 100 patients will be randomised by computer generated random number sequence into three groups. All patients who are diagnosed as B12 deficiency will be administered intravenous, intramuscular and nasal B12 based on treatment protocol. The response in hematological parameters will be assessed on 07th, 14th and 28th day of treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- None
Eligibility Criteria
- Ages
- 18.00 Year(s) to 80.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •All patients diagnosed with B12 deficiency anaemia.
- •Willingness to give consent.
Exclusion Criteria
- •Pregnant females
- •All other causes of anaemia
- •Requiring blood transfusion at initiation of therapy.
Outcomes
Primary Outcomes
COMPARE THE CHANGE IN HEMATOLOGICAL PARAMETERS (HAEMOGLOBIN, MEAN CORPUSCULAR VOLUME)
Time Frame: COMPARE THE CHANGE IN HEMATOLOGICAL PARAMETERS (HAEMOGLOBIN, MEAN CORPUSCULAR VOLUME) ON DAY 14 AND DAY 28 IN EACH GROUP (INTRAVENOUS, INTRAMSCULAR AND NASAL B12 TREATMENT AS PER ESTABLISHED GUIDELINES)
Secondary Outcomes
No secondary outcomes reported
Investigators
Rahil Arora
Armed Forces Medical College