Consequence of Injectable Platelets Rich Fibrin Versus Microosteopeforation on Root Resorption During Orthodontic Intrusion of Incisor Teeth

Phase 1

• Conditions: Compare the Effect of Injectable Platelets Rich Fibrin and Micro-osteoperforations on Root Resorption During Orthodontic Intrusion of Incisors
• Interventions: Combination Product: injectable platelet rich fibrin and microosteoperforation

• Registration Number: NCT05958498
• Lead Sponsor: Al-Azhar University

Brief Summary

Consequence of injectable platelets rich fibrin versus microosteopeforation on root resorption during orthodontic intrusion of incisor teeth

Detailed Description

Consequence of injectable platelets rich fibrin versus microosteopeforation on root resorption during orthodontic intrusion of incisor teeth: A comparative clinical study

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-15
• Study First Submitted QC: 2023-07-15
• Last Update Submitted: 2023-07-15
• Study First Posted: 2023-07-24
• Last Update Posted: 2023-07-24
• Study Start: 2023-12
• Primary Completion: 2024-06
• Study Completion: 2024-08

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• 1. Patients with age range between 12-16 years. 2. Overbite > 40% indicated for maxillary intrusion. 3. Mild to moderate crowding of upper incisors. 4. All permanent teeth erupted (excluding 3rd molars). 5. No previous orthodontic treatment. 6. Good oral hygiene with no previous periodontal surgery.

Exclusion Criteria

1. • Transverse and/or vertical skeletal dysplasia or craniofacial malformation. 2. Retained primary or missing permanent teeth in the maxillary anterior area, and any kind of tooth/root shape anomaly.

2. Patients with root resorption, impacted canines, or dental anomalies. 4. Poor oral hygiene 5. Present or history of periodontal diseases. 6. Systemic diseases or regular use of medications that could interfere with orthodontic tooth movement.

3. History of trauma affecting the maxillary incisors. 8. Endodontically treated upper anterior teeth.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I	injectable platelet rich fibrin and microosteoperforation	who will receive intrusive arches after leveling and alignment assisted with i-PRF according to standardized protocol
Group II	injectable platelet rich fibrin and microosteoperforation	Will includes 9 patients who will receive intrusive utility arches after leveling and alignment assisted with (MOPs) according to standardized protocol.

Primary Outcome Measures

Name	Time	Method
to compare the effect of injectable platelets rich fibrin and micro-osteoperforations on root resorption during orthodontic intrusion of incisors.	post interventionalal at 6months	amount of root resorption

Trial Locations

Locations (1)

AlAzhar university; 🇪🇬 Cairo, Egypt