Maintenance of Anaesthesia With Sevoflurane Versus Propofol and the Occurrence of Postoperative Headache.
Overview
- Phase
- Not Applicable
- Intervention
- Sevoflurane
- Conditions
- Headache
- Sponsor
- Attikon Hospital
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- incidence of postoperative headache (yes or no)
- Last Updated
- 6 years ago
Overview
Brief Summary
Postoperative headache is a major issue after general anaesthesia and surgery. The aim of this study is to investigate the possible difference in the occurrence of postoperative headache when general anaesthesia is maintained with propofol, which is supposed to have protective effects on migraine patients, versus sevoflurane.
Detailed Description
Postoperative headache is a major issue after general anaesthesia and surgery. The aim of this study is to investigate the possible difference in the occurrence of postoperative headache when general anaesthesia is maintained with propofol, versus sevoflurane. Propofol acts throught a GABA, and is known to have a therapeutic effect on migraine patients with accute attacts. However, its role on postoperative headache has not been studied, when used for maintainance of anaesthesia, this study aims to investigate the occurrence of headache after anaesthesia and surgery, when patients receive randomly two different anaesthetics: propofol and sevoflurane.
Investigators
Chrysanthi Batistaki
Assistant Professor of Anaesthesiology
Attikon Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA I-III
- •scheduled operation under general anaesthesia
- •operations \<4 hours
- •minorgynaecological operatios (leiomyomectomy)
- •hernia repair
- •arthroscopic procedurs
- •minor orthopaedic operations without the use of tourniquet or cement
- •saphenectomy
- •minor urologic operations
- •minor other operations of general surgery
Exclusion Criteria
- •age \<18 and \>65 years old
- •Diseases of the central nervous system (ie Parkinsons's disease, Multiple sclerosis, previous ischaemic attack, hydrocephalus, seizure disorder, etc)
- •Psychosis under medication
- •Cognitive impairement or/and inability to fill in the questionaires
- •Allergy or contraindication to the study protocol included drugs
- •Operations of more than 4 hours duration
- •Head and neck procedures, procedures with neck extension (eg thyroidectomy), ENT procedures
- •renal impairement
- •hepatic impairement
- •patient refusal
Arms & Interventions
Sevoflurane
Sevoflurane for maintainance of anaesthesia. Dose 1 MAC adjusted according to the Bispectral Index (BIS) indication (maintained 40-50).
Intervention: Sevoflurane
Propofol
Total intravenous anaesthesia with propofol for maintainance of anaesthesia.Dose adjusted according to the Bispectral Index (BIS) indication (maintained 40-50). Initial dose 10 mg/kg/h for10 min, 8 mg/kg/h for 10 min and then 6 mg/kg/h).
Intervention: Propofol
Outcomes
Primary Outcomes
incidence of postoperative headache (yes or no)
Time Frame: up to 24 hours postoperatively
Rate of postoperative headache in patients receiving sevoflurane versus propofol (yes or no headache)
Secondary Outcomes
- Nausea and vomiting(up to 24 hours postoperatively)