The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing

Not Applicable

• Conditions: Gingival Bleeding
• Interventions: Drug: Chlorhexidine; Drug: Pomegranates peel extract

• Registration Number: NCT02939092
• Lead Sponsor: Cairo University

Brief Summary

To evaluate the clinical effectiveness of mouthwash containing pomegranate peel extract and chlorhexidine mouthwash on bleeding on brushing and counting of streptococcus mutans among a group of Egyptian children with permanent dentition.

Detailed Description

To evaluate the clinical effectiveness of mouthwash containing pomegranate peel extract and chlorhexidine mouthwash on bleeding on brushing and counting of streptococcus mutans among a group of Egyptian children with permanent dentition.

PICO:

Population (P): Children with full permanent dentition. Intervention (I): Pomegranates peel extract. Comparator (C): Chlorhexidine.

Outcome(O):

Primary outcome: Bleeding on brushing, criteria:Asking patient, unit:Binary. Secondary outcome:Counting streptococcus mutans, criteria: Agar plate, unit: CFUs/mL

Study Timeline

• Study First Submitted: 2016-10-11
• Study First Submitted QC: 2016-10-18
• Study First Posted: 2016-10-19
• Status Verified: 2018-01
• Study Start: 2018-01
• Primary Completion: 2018-01
• Last Update Submitted: 2018-01-23
• Last Update Posted: 2018-01-24
• Study Completion: 2018-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• children aged 12-15 years old.
• Cooperative children.
• Both genders.
• Medically free.

Exclusion Criteria

• Children undergoing orthodontic treatment.
• Children using any other oral hygiene aid other than routine teeth brushing.
• Children with known history of allergy to any mouth rinse or drug.
• Parents unable to give informed consent.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Chlorhexidine	Chlorhexidine	Chlorhexidine mouthwash is antiplaque treatment and effective against gingivitis
Pomegranate peel extract	Pomegranates peel extract	Pomegranate is antimicrobial, anti inflammatory and antioxidant

Primary Outcome Measures

Name	Time	Method
Bleeding on brushing, Measurement: asking patient , Unit: Binary	2 weeks

Secondary Outcome Measures

Name	Time	Method
Counting streptococcus mutans, Measurement: Agar plate, Unit: CFUs/mL	2 weeks