COpeptin in Critically Ill Paediatric and Neonatal Intensive Care Patients and Its Association With Arterial Hypotension. A Single-centre Prospective Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 170
- 试验地点
- 1
- 主要终点
- Blood copeptin in arterial normo- and hypotension
研究概览
简要总结
Blood copeptin will be measured during the routine treatment of neonates, children and adolescents on the Intensive Care Unit of the University Children's Hospital Zurich at different time points (admission, 12, 24, 48, 96, 168 hours after admission). These values will be primarily analysed for their variability and their association with arterial hypotension. Blood samples will be drawn together with otherwise medically indicated blood withdrawals to avoid extra harm. Further, copeptin values will be compared to clinical and vital parameters, all of them open-label available during clinical routine. Copeptin's predictive value for patients' outcome will be analysed as secondary outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: first day of life until 18th birthday.
- •Ability of the care taker or the adolescent (if≥14 years of age) to understand verbal and written instructions and informed consent in German.
排除标准
- •Care taker or adolescent (if ≥14 years of age) unwilling to give written informed consent.
- •Care taker or adolescent (if ≥14 years of age) not understanding German and without a family member able to translate.
- •Adolescent (if ≥14 years of age) unwilling to give written informed consent following sedation < 24 hours.
- •Care takers of long-term sedated (>24 hours) adolescents (if ≥14 years of age) unwilling to give written informed consent or not present within 24 hours.
结局指标
主要结局
Blood copeptin in arterial normo- and hypotension
时间窗: Up to 168 hours.
Average change of blood copeptin in patients with both arterial normo- and hypotension and different pathologies.
次要结局
- Length of respiratory support(Up to 168 hours.)
- Length and dose of catecholamine therapy(Up to 168 hours.)
- Length of stay on the intensive care unit(Up to 168 hours.)
- Rate of death(Up to 168 hours.)
研究者
Vincenzo Cannizzaro
Vice-head Department of Pediatric Intensive Care and Neonatology
University Children's Hospital, Zurich