Donor and Recipient Mismatch in Liver Transplantation - Time for Reconsideration?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,146
- 试验地点
- 1
- 主要终点
- Patient survival
研究概览
简要总结
This observational study aims to investigate the impact of gender disparity between donors and recipients on long-term outcomes after liver transplantation (LT). The study aims to answer the following question:
Does gender mismatch lower the possibility of survival after liver transplantation? Participants demonstrate gender dicrepancies between donors and recipients as regular concept in LT. The retrospective cohort study investigates the impact over a long-term follow up of 10 years.
详细描述
The study involves patients who undergo liver transplantation at the Ajmera Transplant Centre Toronto from 2014 until 2022. The observation period ended at the first January 2025 to provide a minimal follow up of 24 months.
Liver transplant recipients with gender mismatch (A) will be compared with liver transplant recipients without gender mismatch (B).
Liver transplantation is the only curative treatment for people with end stage liver disease. Gender mismatch between donor and recipient, particularly, the combination of a female donor to male recipient has been controversial in the past. Identifying risk factors that could affect the survival of the graft and recipient is of the utmost importance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over the age of 18
排除标准
- •Cases of retransplantation
- •Combined organ transplantation
- •Cases with >30% of missing values
研究组 & 干预措施
GM +
Liver transplant recipients with gender mismatch
GM -
Liver transplant recipients without gender mismatch
结局指标
主要结局
Patient survival
时间窗: Liver transplantation between 01.01.2014 and 01.01.2022, Patient Survival: observatory period between 01.01.2014 and 01.01.2024
Overall survival of patients who underwent liver transplantation at the Ajmera transplant centre toronto between 2014 and 2022
次要结局
未报告次要终点
研究者
Nicola Sariye Pollmann
Principal Investigator
University of Jena