The effect of dietary modification on multiple sclerosis.

Not Applicable

Conditions: Multiple Sclerosis.
Multiple sclerosis

Registration Number: IRCT20181113041641N1

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: ietary modification may improve quality of life and fatigue severity in Multiple Sclerosis (MS) patients. Given this, there is a growing interest in healthy diets, especially Mediterranean based. The goal of this study was to explore the e?ects of a modi?ed Mediterranean (mMeD) dietary intervention in Quality Of Life (QOL), and severity of fatigue in MS participants. About 180 Relapsing-Remitting MS patients randomly assigned to follow/not follow the mMeD for 6 months. Primary endpoints were related to dietary adherence and study completion. Clinical endpoints were evaluated Multiple Sclerosis Quality Of Life-54 items, Fatigue Severity Scale (FSS-9), and Visual Analog Fatigue Scale. Data were analyzed by SPSS 24. Of 261 screened patients (July 2018–February 2019), 180 were eligible and willing to commit. 68/90 as mMeD and 79/90 as control group completed the study. Self-reported adherence was excellent (95%). The majority of mean changes for QOL were statistically significant (P < .001). As well, Mean change on the FSS-9 was -9.8 ± 11.5 compared to +0.3 ± 4.2 for controls (P < .001). This regimen improved fatigue and some components of QOL in RRMS patients. Larger scale and longer duration trials to assess the role of diet as a disease modifier in MS should be conducted.

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 160

Inclusion Criteria

Age between 20-60 years
Having basic literacy.
Writing ability and memory strength
Good mental conditions for the continuation of the study

Exclusion Criteria

Participating in other interventional studies at the same time.
Having the other acute and severe illness
Regular and periodic consumption of special dietary supplement or sport-specific diets
The full-dose intake of oral corticosteroides
Continues and daily cigarette smoking
People who are waiting for abdominal surgery