The Effects of Resistance Training Intensity on Muscular Hypertrophy and Strength in Young, Resistance Trained Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Muscle Volume
研究概览
简要总结
When practicing weightlifting regularly the body makes new proteins within the muscle.
These new proteins can increase the size of the cells within the muscle to make them larger, a process called hypertrophy. The common convention surrounding gains in skeletal muscle size and strength is that heavy weights are needed. In contrast, lifting lighter weights are thought to be required to induce muscular endurance and not to promote growth. However, it has previously been shown in untrained men that lifting lighter weights results in similar gains in muscle mass and strength as lifting heavier weights. The purpose of this study is to examine how performing resistance training of different intensities (light or heavy weights) affects the degree of muscle growth and strength gain in individuals who are already resistance training.
This information will be valuable when designing exercise protocols for increasing muscle size and strength at all ages, or in individuals returning from injury, as a way to stimulate muscle growth and promote strength gains without the need to lift heavy weights.
详细描述
Patients will visit the laboratory of Dr. Stuart Phillips at the Ivor Wynne Centre (IWC) at McMaster University for 14 weeks for a number of tests and exercise sessions.
Each visit will be as follows:
Visit 1:
Upon obtaining consent, eligible participants will complete a medical screening questionnaire to determine their readiness to perform exercise as well as a filling out a form to determine subject characteristics. Participants will begin collecting data for their first 3-day diet record. They will record their diet (2 weekdays and a weekend day) again at 6 weeks (mid-protocol) and at 12 weeks of the study.
Visit 2:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 18-30 years old
- •Non-obese (Body mass index less than 30 kg/m2)
- •Non-smoker
- •Healthy based on questionnaire responses (see
排除标准
- •Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)
- •Exclusion Criteria:
- •Allergies to milk proteins (whey or casein)
- •Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- •Arthritic conditions
- •Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
- •A history of neuromuscular problems
- •Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
研究组 & 干预措施
30%
Training at 30% 1RM
干预措施: 30% 1RM (Behavioral)
80%
Training at 80% 1RM
干预措施: 80% 1RM (Behavioral)
结局指标
主要结局
Muscle Volume
时间窗: 0 weeks (baseline) and 12 weeks
Change from baseline at 12 weeks Measured via 4 compartment model
次要结局
- Gene expression(0 weeks (baseline) and 12 weeks)