Preoperative Serum Albumin and Duration of Intraoperative Hypotension on Postoperative Acute Kidney Injury: a Retrospective Cohort Analysis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Peking University First Hospital
- Enrollment
- 37610
- Locations
- 1
- Primary Endpoint
- incidence and odds ratio of postoperative acute kidney injury
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Acute kidney injury is one of major adverse postoperative complications. research about postoperative acute kidney injury conclude that low preoperative albumin and intraoperative hypotension is associated to postoperative acute kidney injury. However, due to ethic issue and nonlinear realtionship between these factors and postoperative acute kidney injury, the exact threshold of these two risk factors were not be able to identified. The research tried to locate the exact threshold with implementation of penalized splines by generalized additive model.
Investigators
Yan Zhou, MD
Principal Investigator
Peking University First Hospital
Eligibility Criteria
Inclusion Criteria
- •adult non-cardiac, non-obsteric, non- kidney elective surgery patients
Exclusion Criteria
- •patients aged \<18 y emergency surgeries without arterial blood pressure cardiac surgeries obstetric surgeries kidney surgeries under local infiltration or MAC first SBP \<100 mmHg
Outcomes
Primary Outcomes
incidence and odds ratio of postoperative acute kidney injury
Time Frame: 30 days postoperatively in hospital
incidence and odds ratio of postoperative acute kidney injury