The effect of combinant antioxidant supplementation on blood in patient with rheumatoid arthritist
- Conditions
- Rhumatoid arthritis.Seropositive rheumatoid arthritis
- Registration Number
- IRCT201203116934N2
- Lead Sponsor
- Pharmaceutical research center, Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 40
People with diagnosis of Rheumatoid arthritis disease according to American College of Rheumatology criteria (ACR) is confirmed. The doctor diagnosed according to criteria ACR (at least 4 criteria for six weeks : 1 - morning stiffness in the joint for at least an hour or more 2 - articular arthritis in three areas or more4: hand joint arthritis 5- symmetrical arthritis 5 - rheumatoid nodules 6 - positive rheumatoid factor 7 - typical radiographic changes in the wrist and hand) in adult patients with rheumatoid arthritis and patients visiting the doctor, at least for the past two months have not had a treatment change. Selected at random from among eligible women 30 -60 years old admitted with mild to moderate range of severity of illness would be a specialist; if DAS (Disease Activity Score) below 3/2 is a mild disease and the DAS (Disease Activity Score) is between 3/2-5/1, moderate severity is defined .
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determine and compare the clinical improvement in patients with rheumatoid arthritis before and after intervention. Timepoint: Before and 3 month after intervention. Method of measurement: DAS questionnaire.;ADMA concentrations in the serum of patients with rheumatoid arthritis before and three months after the administration of antioxidants. Timepoint: Previous intervention three months after the intervention began. Method of measurement: ELISA method.;Determine changes in serum VEGF rheumatoid arthritis before and three months after the administration of antioxidants. Timepoint: Before and 3 month after intervention. Method of measurement: ELISA.
- Secondary Outcome Measures
Name Time Method Investigate the effects of antioxidant drugs. Timepoint: Before and three months after intervention. Method of measurement: Questionnaire.