Analysis of Gene Expression in Femoroacetabular Impingement (FAI)

• Conditions: Femoroacetabular Impingement

• Registration Number: NCT04988659
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Femoral acetabular impingement (FAI) is a common disease of the hip joint. In this study, whole-genome sequencing was used to further explore the pathogenesis of this disease.

Detailed Description

Femoral acetabular impingement (FAI) is a group of chronic hip pain caused by the impact between the proximal femur and the edge of the acetabulum due to the anatomical abnormality of the hip joint, which damages the labrum and adjacent cartilage, and causes limited hip movement, especially limited flexion and internal rotation. However, the specific etiology of FAI is still unknown at present. The application of genome-wide, exon and transcription research methods to the study of hip impaction syndrome can uncover key differentially expressed genes and provide a theoretical basis for the study of FAI.

Study Timeline

• Study Start: 2021-03-30
• Primary Completion: 2021-05-30
• Status Verified: 2021-06
• Study First Submitted: 2021-06-25
• Study First Submitted QC: 2021-07-26
• Last Update Submitted: 2021-07-26
• Study First Posted: 2021-08-03
• Last Update Posted: 2021-08-03
• Study Completion: 2021-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• The patient underwent preoperative imaging and was diagnosed with FAI. The patient complained of pain in the hip, hip, or thigh, and had a positive hip flexion impact test.

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Exclusion Criteria

• Patients with hip surgery history, hip osteoarthritis, necrosis of the femoral head, hip infection, hip dysplasia and other hip diseases.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The patients were clinically diagnosed with FAI (femoral acetabular impingement) and underwent arthroscopic surgery, then clinical samples were collected.	The patient was diagnosed with FAI, and conservative treatment was ineffective for an average of 6 months.	Peripheral blood from 100 patients with femoral acetabular impingement syndrome was collected and DNA was extracted.

Trial Locations

Locations (1)

Peking University Third Hospital; 🇨🇳 Beijing, China