Does Oxytocin Modulate Rewarding Effect of Metaphorical Compliments Fluctuating With Women's Fertility and Luteal Phase in a Romantic Context
Trial Snapshot
- Phase
- Early Phase 1
- Status
- Completed
- Sponsor
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Oxytocin effect on neural activity as assessed via fMRI towards reward between fertility and luteal phases
Study Overview
Brief Summary
The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.
Detailed Description
To investigate whether oxytocin (24IU) might interact with female sex hormone in modulating the rewarding effect of compliment to women in a romantic context.
The study employs a double-blind, within-subject, placebo-control design. Women will be administered with the same drug twice (oxytocin or placebo) respectively the fertile and luteal phase followed by a MRI scanning. During fMRI participants will rate men's attraction based on their facial pictures of average attractiveness associated with compliments of different combination of form and topic. Each male face will be paired with two sentences of the same kind. After the fMRI participants will recall the judgment followed by a memory test during which they have to indicate whether the they have seen the face during scanning (old) or whether it is an unknown face (new).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 25 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Single in the past 3 months
- •Healthy subjects with regular menstrual cycle
Exclusion Criteria
- •Pregnant, menstruating, taking oral contraceptives
- •metal implanted, with tatoo, or hair dyed within 6 months
- •participated in another intranasal experiment within 6 months
- •with a history of past or current psychiatric or neurological disorder
Arms & Interventions
oxytocin fertility
intranasal oxytocin administration (24IU) in women's fertility phase (LH>40 mIU/ml)
Intervention: Oxytocin (Drug)
placebos fertility
intranasal placebo administration (24IU) in women's fertility phase (LH>40 mIU/ml)
Intervention: Placebos (Drug)
oxytocin luteal
intranasal oxytocin administration (24IU) in women's luteal phase (LH<30 mIU/ml)
Intervention: Oxytocin (Drug)
placebos luteal
intranasal placebos administration (24IU) in women's luteal phase (LH<30 mIU/ml)
Intervention: Placebos (Drug)
Outcomes
Primary Outcomes
Oxytocin effect on neural activity as assessed via fMRI towards reward between fertility and luteal phases
Time Frame: 45min-120min after treatment
Effects of oxytocin versus placebo nasal spray on neural processing of reward will be compared between different cycle phases
Secondary Outcomes
No secondary outcomes reported
Investigators
Keith Kendrick
Professor
University of Electronic Science and Technology of China