General Anesthesia intubation response

Not yet recruiting

• Registration Number: CTRI/2021/12/038529
• Lead Sponsor: self

Brief Summary

direct laryngoscopy and intubation may results in increase in blood pressure and heart rate which inturn leads to myocardial ischemia,cerebral hemorrhage and cardiac arrest in hemodynamicaly instable and susceptible patients.minimizing persistent and severe alterations in heart rate and blood pressure is critical.usual recommendations suggest maintaining heart rate and blood pressure at 20% of the basal value.alpha 2 receptor agonists decrease the catecholamine release thus can diminish the hyper dynamic status which renders the patients prone to ischemia.Hemodynamic stabilization,during and after the operations is most important mechanism by which the aplha2 receptor agonists reduce perioperative ischemia.thus we compared the drugs clonidine and tizanidine on the anesthetic requirements and the recpvery from general anesthesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-09-12
• Study Start: 2021-12-12

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

willing patients,ASA1 &2 ,ELECTIVE CASES.

Exclusion Criteria

ASA 3 OR MORE PREGNANT AND LACTATING MOTHER ANTICIPATED DIFFICULT AIRWAYUNCONTROLLED CHRONIC ILLNESS LIKE DIABETES MELLITUS,ASTHMA,SMOKERS,ON MONOAMINA OXIDASE INHIBITORS,PATIENTS WITH PREVIOUS RENAL AND HEPATIC DYSFUNCTION,HEAR DISEASES,VALVULAR HEART DISEASE,ELECTROPHYSICAL ABNORMALITIES,AND OTHER HEMODYNAMIC INSTABILITY.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This study attempts to survey the effects of the oral premedication Tizanidine and clonidine on intraoperative hemodynamic responses during tracheal intubation	at intubation,1,3 abd 5 min after intubation

Secondary Outcome Measures

Name	Time	Method
calculation the induction dose of propofol in general anesthesia.	30min

Trial Locations

Locations (1)

department of anesthesiology,general surgery operation theatre second floor.; 🇮🇳 Pondicherry, PONDICHERRY, India

department of anesthesiology,general surgery operation theatre second floor.

🇮🇳Pondicherry, PONDICHERRY, India

elavanya

Principal investigator

9629181969

dr.lavanya08@gmail.com