Response to Endotracheal Tube Intubation at Different Time of Fentanyl Given During Induction

Not Applicable

Completed

• Conditions: Intubation, Intratracheal

• Registration Number: NCT03728686
• Lead Sponsor: Chien-Chung,Huang

Brief Summary

Opioids have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine. Patients'details will be recorded too.

Detailed Description

Laryngoscopy and intubation often provoke hypertension and tachycardia due to the stimulation both sympathetic and sympathoadrenal activities. While the adverse hemodynamic effects of laryngoscopy and endotracheal intubation can precipitate myocardial ischemia, even in patients without hypertension, the responses are exaggerated in patients with hypertension . In the previous studies , many drugs, including opioids and beta-blockers, have been used to modify the hemodynamic response associated with laryngoscopy and tracheal intubation. To seek the correlation of Fentanyl given time, we will analysis the data collected from vital signs monitoring machine.

All patients were premedicated with Midazolam 0.1mg/kg , Lidocaine 0.5mg/kg (L), Propofol 2mg/kg (P), Rocuronium 1mg/kg (R) before induction of general anesthesia. Laryngoscopy lasting a maximum of 30 s was attempted 3 min after administration of the induction agents. Fentanyl 2mcg/kg was given at different time before intubation.

Study Timeline

• Study Start: 2016-12-16
• Primary Completion: 2018-07-30
• Study Completion: 2018-07-30
• Study First Submitted: 2018-10-31
• Study First Submitted QC: 2018-10-31
• Status Verified: 2018-11
• Study First Posted: 2018-11-02
• Last Update Submitted: 2018-11-04
• Last Update Posted: 2018-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• with American Society of Anesthesiologists (ASA) physical status classification 1&2
• undergo elective surgery
• intubation

Exclusion Criteria

• Opioids allergy history

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
systolic blood pressure	0-10 minutes during induction	systolic blood pressure
heart rate	0-10 minutes during induction	heart rate
diastolic blood pressure	0-10 minutes during induction	diastolic blood pressure

Trial Locations

Locations (1)

MacKay Memorial Hospital; 🇨🇳 Taipei, Taiwan