ISRCTN22669537
Completed
未知
A multi-centre double blind randomised controlled trial of aspirin and/or folate supplementation for the prevention of recurrent colorectal adenoma
Cancer Research UK (CRUK) (UK)0 sites1,000 target enrollmentJuly 1, 2001
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Recurrent colorectal adenomas
- Sponsor
- Cancer Research UK (CRUK) (UK)
- Enrollment
- 1000
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
2008 results in http://www.ncbi.nlm.nih.gov/pubmed/18022173
Investigators
Eligibility Criteria
Inclusion Criteria
- •Eligible patients who have had:
- •1\. Removal of adenomas greater than 0\.5 cm after fixation or adenomas greater than 0\.7 cm at the time of removal, within the last six months
- •2\. A previous history of removal of such adenomas and have had adenoma of any size removed in the six months prior to recruitment These adenomas will be histologically confirmed and removed by either colonoscopy, flexi\-sigmoidoscopy or via Transanal Endoscopic Microsurgery (TEMS) procedure
Exclusion Criteria
- •1\. Over 75 years at time of recruitment
- •2\. Serious medical conditions likely to preclude successful completion of the trial
- •3\. Existing use of prescribed Non\-Steroidal Anti\-Inflammatory Drugs (NSAIDs) including aspirin
- •4\. Known aspirin intolerance or sensitivity
- •5\. Active bleeding disorders or upper Gastrointestinal (GI) ulceration, including use of anticoagulants
- •6\. Previous resection of the large bowel
Outcomes
Primary Outcomes
Not specified
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