ISRCTN10994757
Completed
未知
A multi-centre, double-blind, randomised, controlled clinical trial of rifaximin to reduce infection in patients admitted to hospital with decompensated cirrhosis
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Decompensated cirrhosis
- Sponsor
- Imperial College London
- Enrollment
- 78
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
2021 Thesis results in https://doi.org/10.25560/97104 (added 30/08/2023)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Clinical/biochemical/radiological \+/\- histological diagnosis of cirrhosis
- •2\. Hospital admission with complication of cirrhosis (e.g. alcoholic hepatitis, sepsis, variceal bleeding)
- •3\. Commencement on antimicrobial therapy
- •4\. Aged 18 \- 80 years
Exclusion Criteria
- •1\. C.difficile infection
- •2\. HIV antibody positive
- •3\. Immunosuppression (excluding low dose steroids/steroid sparing agents for AIH \<20 mg or equivalent of prednisolone)
- •4\. Advanced disseminated Hepatocellular Carcinoma or invasive carcinoma
- •5\. eGFR \< 30 on screening/randomisation
- •6\. End\-stage/severe cardiac, pulmonary or kidney disease
- •8\. Colitis or coeliac disease
- •9\. Pregnancy
- •10\. Already receiving rifamixin
Outcomes
Primary Outcomes
Not specified
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