Investigation of the influence of the human microbiome on the pathogenesis and recurrence probability of giant cell arteritis
Recruiting
- Conditions
- M31.6Other giant cell arteritis
- Registration Number
- DRKS00032993
- Lead Sponsor
- niversitätsklinikum Bonn
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Diagnosis of giant cell arteritis
Exclusion Criteria
chronic infection (viral, funghi, bacteria) including HIV, Hepatitis B/C
acute infection with usage of antibiotics less then 90 days before screening
major gastro-intestinal surgery <5 years from screening
gastro-intestinal bleeding <90 days before screening
inflammatory bowel disease (confirmed bioptically)
bullimia, anorexia nervosa, adipositas (BMI = 40)
intake of high dosage of probiotics (>109 KBE per day) <90 days before screening
not controlled Diabetes mellitus
Malignancy within one year (except for squamous skin - and basal skin carcinoma without metastasis, cervix carcinoma with curative surgery, CTCL)
known abuse of alcohol oder drugs.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant differences in the composition of the microbiome
- Secondary Outcome Measures
Name Time Method Influence of the microbiome on therapy response e.g. increased probability of recurrence with accumulation of specific microbiome species