Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
Phase 2
Completed
- Conditions
- Miscarriage
- Interventions
- Registration Number
- NCT03479879
- Lead Sponsor
- Ain Shams University
- Brief Summary
To compare the effectiveness of estradiol pretreatment with misoprostol and vaginal misoprostol alone in induction of second trimestr miscarriage.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- Maternal age more than 18 years old (age of legal consent).
- Gestational age between 12-26 weeks.
- Hb level > 10 g/dL.
- BMI between 25 kg/m2 and 35 kg/m2.
- Missed abortion.
- Living fetus with multiple congenital malformations incompatible with life.
- PPROMS with drained liquor and parents are consenting for termination of pregnancy.
Exclusion Criteria
- Maternal age less than 18 years old.
- Gestational age less than 12 weeks or more than 26 weeks.
- Hb level < 10 g/dL.
- Scared uterus (previous myomectomy - cesarean section - hysterectomy and ruptured uterus).
- Polyhydramnios.
- Anencephaly.
- Fibroid uterus.
- BMI less than 25 kg/m2 and more than 35 kg/m2.
- Coagulopathy.
- Previous attempts for induction of abortion in the current pregnancy.
- Allergy to misoprostol or estradiol.
- Placenta previa.
- Medical disorder that contraindicate induction of abortion (e.g. heart failure).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo + Misoprostol Placebo Oral Tablet - Placebo + Misoprostol Misoprostol - Estradiol + Misoprostol Estradiol - Estradiol + Misoprostol Misoprostol -
- Primary Outcome Measures
Name Time Method Duration of induction of abortion 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ain Shams University Maternity Hospital
🇪🇬Cairo, Egypt