临床试验/CTRI/2025/02/080802

CTRI/2025/02/080802已完成Phase 3 4

Effect of etomidate versus propofol on hemodynamic parameters for induction in recipients undergoing liver transplant surgery: a randomized control trial

Institute of Liver and Biliary Sciences1 个研究点分布在 1 个国家目标入组 50 人开始时间: 2025年3月10日最近更新: 2025年9月4日

试验速览

阶段: Phase 3 4
状态: 已完成
发起方: Institute of Liver and Biliary Sciences
入组人数: 50
试验地点: 1
主要终点: To study change in mean arterial pressure during induction every minute till 10

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Hypothesis : Etomidate will give better hemodynamic stability as induction agent than propofol

Study population: Patients will be assigned to two groups of 25 each.

Group A (n=25) (Induction with Propofol)

Group B (n=25) (Induction with Etomidate)

Study design: Prospective randomized controlled trial

Study period: 6 months

研究设计

研究类型: Interventional
分配方式: Randomized
盲法: Participant, Investigator and Outcome Assessor Blinded

入排标准

年龄范围: 18.00 Year(s) 至 60.00 Year(s)（—）
性别: All

入选标准

•Age 18 to 60 years Patients undergoing Liver Transplant Recipient Surgery.

排除标准

•Patients who do not consent for the study.
•Recipients for Acute liver failure and acute on chronic liver failure Patients with preexisting cardiac disease Patients with Cirrhotic Cardiomyopathy Patients having allergy to propofol or etomidate.

结局指标

主要结局

To study change in mean arterial pressure during induction every minute till 10

时间窗: 10 minutes

minutes.

时间窗: 10 minutes

次要结局

To compare hemodynamic parameters: HR-heart rate, SBP- systolic blood pressure, DBP- Diastolic blood pressure, CO- cardiac output, SV- stroke volume, SVV- Stroke volume variation during induction every minute till 10 minutes.
To compare use of vasopressor during induction every minute till 10 minutes.
To compare rate of complication like myoclonus and pain on injection during induction every minute till 10 minutes.(10 minutes after induction)

研究者

发起方

Institute of Liver and Biliary Sciences

申办方类型

Research institution and hospital

责任方

Principal Investigator

主要研究者

Dr Ishan Verma

Institute Of Liver and Biliary Sciences

研究点 (1)

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