The role of branched-chain amino acids (BCAAs) in the stimulation of skeletal muscle protein synthesis and glucose uptake in healthy, young volunteers
- Conditions
- insulin resistanceMuscle loss1001842410028302
- Registration Number
- NL-OMON53406
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 28
• Aged from 18-35 years
• 18.5 < BMI < 30 kg·m2
• Recreationally active (performing non-competitive physical exercise at least
one time per week for minimally 30 minutes)
• Smoking
• Diabetes (Type 1, Type 2, or genetic form of diabetes)
• Any diagnosed cardiovascular (heart) disease or high blood pressure (>=140
mmHg systolic and/or >=90 mmHg diastolic)
• Chronic use of any prescribed or over the counter pharmaceuticals (excluding
oral contraceptives and contraceptive devices)
• Known allergy to lidocaine
• Prone to keloid forming (i.e. hyperplastic growth of scars).
• Regular use of dietary protein and/or amino acid supplements (>3 times per
week)
• Currently involved in a structured progressive resistance training programme
(>3 times per week)
• A personal or family history of thrombosis (clots), epilepsy, seizures, or
schizophrenia.
• Any previous motor disorders or disorders in muscle and/or lipid metabolism
• Presence of an ulcer in the stomach or gut and/or strong history of
indigestion
• Known severe kidney problems
• Pregnant or breastfeeding
• Unable to give consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Muscle protein synthesis rates, expressed as fractional synthetic rate (FSR),<br /><br>in the basal and postprandial state. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Muscle glucose uptake (i.e. direct measure of muscle insulin sensitivity).<br /><br>Fat and fat-free mass (via DXA scan)</p><br>