A Clinical trial to study role of probiotics on gut permeability and endotoxemia in patients with acute pancreatitis
Not Applicable
- Registration Number
- CTRI/2009/091/000933
- Lead Sponsor
- Anoop Saraya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Patients with AP presenting within the first 72 hours after the onset of abdominal pain or have been nil orally at the time of presentation for up to 5 days.
Exclusion Criteria
(a) Malignancy ,(b) Infection or sepsis related to source other than pancreatic bed, (c) Intra-operative diagnosis of AP,(d) Immunodeficiency,(e) Prior use of probiotics or prebiotics, (f) Pregnant ladies.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect on gut permeability and endotoxemia via prevention of bacterial translocation and restoring the intestinal permeability.Timepoint: At baseline and day 7
- Secondary Outcome Measures
Name Time Method Clinical end point. Mortality, total hospital stay, duration of ICU stay, side effects<br>Biochemical. (i) C-reactive protein (ii) Prealbumin<br>Timepoint: Base line and day 7