A clinical trial study to compare antidepressants in mild to moderate depression in person with epilepsy(PWE)
- Conditions
- Health Condition 1: G40- Epilepsy and recurrent seizures
- Registration Number
- CTRI/2020/11/028899
- Lead Sponsor
- Dr Manjari Tripathi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 0
1.Age >18years
2.Patients with generalized and focal epilepsy on antiseizure medications(ASM)
3.Patients eligible using 21 item Hamiltonââ?¬•s depression rating scale.
1.Patients who scored severe and very severe depression score on Hamiltonââ?¬•s depression rating scale
2.Psychogenic non-epileptic seizures
3.Any women who want to conceive or pregnant women
4.Unable to give consent
5.Patients having intellectual disability.
6.Any terminal illness such that the patient would not be expected to survive long.
7.Patient with significant non- neurological co-morbidities like chronic cardiac, renal and other systemic diseases that can also causes depression
8.Patients with hepatic disease ,renal disease and with prolonged QTc interval.
9.Any condition that, in the judgement of the investigator could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method âÅ?â?To study the difference in efficacy and adverse event profile of antidepressants in mild to moderate depression in PWE at 8 weeks follow up.Timepoint: 8 weeks
- Secondary Outcome Measures
Name Time Method âÅ?â?To study if adjunctive therapy with antidepressants along with standard antiseizure medications has any effect on seizure frequency in PWE at 8 weeks follow up. <br/ ><br>âÅ?â?To assess quality of life, adherence with antidepressants in PWE at 8 weeks follow up <br/ ><br>Timepoint: 8 weeks