Antibiotic Treatment of Community-acquired Pneumonia: a Prospective Comparison of Dutch Guideline Advices.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- UMC Utrecht
- 入组人数
- 2,283
- 试验地点
- 7
- 主要终点
- Day 90 Mortality
研究概览
简要总结
The purpose of this study is to compare the cost(effectiveness) of three existing antibiotic strategies for patients with community-acquired pneumonia admitted to the hospital, but not the ICU.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients admitted to one of the participating hospitals needing treatment for CAP, not being admitted to the ICU are eligible for study inclusion.
- •Admission is defined as hospital stay for more than 24 hours.
排除标准
- •Patients who are readmitted with CAP within 2 weeks after a previous episode are not eligible.
- •Patients with cystic fibrosis are not eligible.
研究组 & 干预措施
Betalactam monotherapy
Preferred empirical treatment for patients in this arm is Beta-lactam monotherapy e.g. co-amoxiclav or ceftriaxone
干预措施: Preferred empirical treatment (Other)
Betalactam combination with macrolide
Preferred empirical treatment for patients in this arm is beta-lactam combination therapy with a macrolide e.g. ceftriaxone and erythromycin
干预措施: Preferred empirical treatment (Other)
Quinolone monotherapy
Preferred empirical treatment for patients in this arm is quinolone monotherapy e.g. moxifloxacin or levofloxacin
干预措施: Preferred empirical treatment (Other)
结局指标
主要结局
Day 90 Mortality
时间窗: 90 days from admission
We will assess all-cause mortality on day 90 from admission from the municipal personal records database
次要结局
- Length of intravenous antibiotic treatment(Participants will be followed for the duration of hospital stay, an expected average of 1 week)
- Length of hospital stay(Participants will be followed for the duration of hospital stay, an expected average of 1 week)
- Tolerability(Participants will be followed for the duration of hospital stay, an expected average of 1 week)
- Complications(Participants will be followed for the duration of hospital stay, an expected average of 1 week)
- Health care costs and non-health care costs(28 days from admission)