Mechanisms of Diabetes Control After Weight Loss Surgery, Sub-study #1
- Conditions
- Gastric BandingGastric Bypass SurgeryType 2 Diabetes
- Registration Number
- NCT01930448
- Lead Sponsor
- St. Luke's-Roosevelt Hospital Center
- Brief Summary
Gastric bypass (GBP) and laparoscopic adjustable banding (AGB) are common procedures that can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of cases. The mechanism and time course of these changes have not been well studied and are poorly understood. The primary aim of this study is to investigate the potential weight-independent mechanisms of diabetes remission after GBP, by comparing GBP and AGB subjects after similar weight loss.
- Detailed Description
All participants will be tested before and then after 10 and 20-30% weight loss after either GBP or AGB surgery. Subjects will undergo an oral glucose tolerance test (OGTT) an isoglycemic intravenous glucose test (IVGT) to assess the incretin effect, a measure of insulin sensitivity by an intravenous insulin sensitivity test (IVGTT) and body composition measurements.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- obese type 2 diabetes individuals scheduled to undergo bariatric surgery by either gastric banding or gastric bypass surgery
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in Incretin Effect Before surgery, 1, 12, and 24 months post Effect of GBP and AGB on incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP)
- Secondary Outcome Measures
Name Time Method Change in Body Composition Before surgery, 12, and 24 months post Body composition measurements to determine body volume, size, and fat
Trial Locations
- Locations (1)
St. Luke's Roosevelt Hospital-New York Obesity Nutrition Research Center
🇺🇸New York, New York, United States