Salivary LL-37 and Periodontal Health in Children Exposed to Passive Smoking
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 主要终点
- Antimicrobial Peptide
研究概览
简要总结
This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)
详细描述
Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.
Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.
LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy children
排除标准
- •Any medications known to affect defense system and periodontium
- •The presence of orthodontic / intraoral appliance
结局指标
主要结局
Antimicrobial Peptide
时间窗: In the first 18 months of study
LL-37 (pg/mL)
次要结局
- Passive smoking measurement(In the first 18 months of study)
研究者
Meltem Karsiyaka Hendek
Assistant Professor
Kırıkkale University