Recurrent miscarriages: Causes, treatment and consequences.
- Conditions
- -recurrent miscarriages -trombophilia -antiphospholipid syndrome
- Registration Number
- NL-OMON20356
- Lead Sponsor
- MC (Leidsch University Mediccal Center)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. > two subsequently miscarriages;
2. Maternal age < 40.
Exclusion Criteria
1. Parental chromosomal abnormalities;
2. Uterus anomalies;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pregnancy outcome.
- Secondary Outcome Measures
Name Time Method 1. To describe maternal immune responses in women with miscarriages compared to women with an ongoing pregnancy and women with a normal pregnancy at different gestational periods;<br /><br>2. To research which role medication (progesteron, anticoagulantia) plays in the immune response and pregnancy outcome;<br /><br>3. To research whether specific KIR genes combined with specific HLA-C ligands determines or influences pregnancy outcome;<br /><br>4. To research the presence of KIR and KAR on NK cells, and their effect on cytokine profiles during pregnancy and pregnancy outcome;<br /><br>5. To research whether the proportion of Th1 cells compared to the proportion of Th2 cells influences pregnancy outcome;<br /><br>6. To study the presence of C4d deposition in placental tissue in patients with recurrent miscarriage in relation to the presence of autoantibodies, allo-antibodies and to pregnancy outcome;<br /><br>7. To determine whether cytokines, chemokines or sHLA-1 in sperm influences pregnancy outcomes.