Primary Spontaneous Pneumothorax and Renal Cell Carcinoma

Recruiting

Conditions: longaandoening: pneumothorax
lung collaps by air in the pleural cavity
pneumothorax
10027664
10038430

Registration Number: NL-OMON54609

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 350

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
-Able to give written informed consent prior to participation in the study.
Subjects must be able to read, comprehend and write at a level sufficient to
complete study related materials.
-Subjects must have a diagnosis of spontaneous pneumothorax (this might be a
2nd PSP if not proven to be related to a known disease or first contralateral
pneumothorax)
-Age: at least 16 years of age at visit 1
-Gender: male or female

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
-Age < 16 years old
-Subjects with claustrophobia making it impossible to perform a CT scan
-Has a history or current evidence of any condition, therapy, or laboratory
abnormality that might confound the results of the trial, interfere with the
subject*s participation for the full duration of the trial, or it is not in the
best interest of the subject to participate, in the opinion of the treating
investigator.
-A CT scan of the thorax is already been performed for this subject within a
year before the PSP
-lung carcinoma
-lung metastases
-Iatrogenic pneumothorax
-secondary spontaneous pneumothorax

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence of pulmonary parenchyma abnormalities which can be found by<br /><br>performing low-dose CT scan of the chest and which are probably related to<br /><br>Birt-Hogg-Dube syndrome in patients presenting with primary spontaneous<br /><br>pneumothorax.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The prevalence of Birt-Hogg-Dube syndrome based on finding the folliculin gene<br /><br>mutation in a cohort of patients with primary spontaneous pneumothorax.<br /><br><br /><br>Other abnormalities in the pulmonary parenchyma found by performing low-dose CT<br /><br>of the chest and probably related to the primary spontaneous pneumothorax.</p><br>