Primary Spontaneous Pneumothorax and Renal Cell Carcinoma (PSP-RCC)

Conditions: pneumothorax, birt hogg dube syndrome, renal cell carcinoma

Registration Number: NL-OMON29526

Lead Sponsor: SFOH

Brief Summary: peer revieuwed journals

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 350

Inclusion Criteria

Able to give written informed consent prior to participation in the study. Subjects must be able to read, comprehend and write at a level sufficient to complete study related materials.
-Subjects must have a diagnosis of spontaneous pneumothorax (this might be a 2nd PSP if not proven to be related to a known disease or the first contralateral pneumothorax)
-Age: at least 16 years of age at visit 1
-Sex: male or female

Exclusion Criteria

-Age under 16
-Subjects with claustrophobia making it impossible to perform a CT scan
-Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject’s participation for the full duration of the trial, or it is not in the best interest of the subject to participate, in the opinion of the treating investigator.
-A CT scan of the thorax is already been performed within a year before the PSP
-lung carcinoma
-lung metastases
-Iatrogenic pneumothorax
-secondary spontaneous pneumothorax

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The prevalence of CT abnormalities possibly related to Birt-Hogg-Dubé syndrome in subjects presenting with a 'primary' spontaneous pneumothorax.

Secondary Outcome Measures

Name	Time	Method
The prevalence of BHD syndrome based on mutation testing in a cohort of patients with PSP<br><br>Other (CT-) abnormalities that are likely related to the cause of PSP<br>