Postoperative effects of preoperative caloric and protein restriction.

Recruiting

• Conditions: ive kidney donors - levende nierdonorenBariatric surgery - bariatrische chirurgieObesity-induced inflammation - Obesitas-geinduceerde inflammationDietary restriction - Dieetrestrictie

• Registration Number: NL-OMON28311
• Lead Sponsor: - Rijksinstituut voor Volksgezondheid en Milieu (RIVM)- Erasmus Medical Center

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Group 1:

1. Live laparoscopic donor nephrectomy;

Exclusion Criteria

Group 1: Allergic to the ingredients of the diet, bilateral abnormalities of the renal arteries, previous operations of the kidney(s) or adrenals gland(s), an open surgical approach.

Group 2: Allergic to the ingredients of the diet, other operations methods than the Roux-en-Y gastric bypass, previous operations of the stomach or duodenum, an open surgical approach, co-morbidity as in diabetes mellitus, morbid obesity caused by genetic defects/syndromes, another preoperative nutritional intervention necessary because of liver abnormalities.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Safety and feasibility of a caloric and protein restricted diet measured by side-effects and metabolic parameters;<br /><br>2. Induction of the protective stress response via a caloric and protein restricted diet, measured by markers of the stress response in tissue (biopsies) and blood.

Secondary Outcome Measures

Name	Time	Method
1. Effect on subjective wellbeing and postoperative recovery after a caloric and protein restricted diet via questionnaires;<br /><br>2. Acute phase response via blood samples.