Gemcitabine in Treating Patients With Persistent or Recurrent Cancer of the Cervix
- Conditions
- Cervical Cancer
- Registration Number
- NCT00006224
- Lead Sponsor
- Gynecologic Oncology Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of gemcitabine in treating patients who have persistent or recurrent cancer of the cervix.
- Detailed Description
OBJECTIVES:
* Determine the antitumor activity of gemcitabine in patients with persistent or recurrent nonsquamous cell carcinoma of the cervix who failed higher priority treatment protocols.
* Determine the toxicity of this regimen in these patients.
OUTLINE: This is a multicenter study.
Patients receive gemcitabine IV over 30 minutes weekly for 3 weeks. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: Approximately 15-37 patients will be accrued for this study within 1 year.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (39)
Jonsson Comprehensive Cancer Center, UCLA
🇺🇸Los Angeles, California, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
Ireland Cancer Center
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Taussig Cancer Center
🇺🇸Cleveland, Ohio, United States
Arthur G. James Cancer Hospital - Ohio State University
🇺🇸Columbus, Ohio, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Tufts University School of Medicine
🇺🇸Boston, Massachusetts, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Walter Reed Army Medical Center
🇺🇸Washington, District of Columbia, United States
Cooper Hospital/University Medical Center
🇺🇸Camden, New Jersey, United States
Brookview Research, Inc.
🇺🇸Nashville, Tennessee, United States
Tom Baker Cancer Center - Calgary
🇨🇦Calgary, Alberta, Canada
University of Alabama at Birmingham Comprehensive Cancer Center
🇺🇸Birmingham, Alabama, United States
Community Hospital of Los Gatos
🇺🇸Los Gatos, California, United States
H. Lee Moffitt Cancer Center and Research Institute
🇺🇸Tampa, Florida, United States
Chao Family Comprehensive Cancer Center
🇺🇸Orange, California, United States
Ellis Fischel Cancer Center
🇺🇸Columbia, Missouri, United States
Duke Comprehensive Cancer Center
🇺🇸Durham, North Carolina, United States
Comprehensive Cancer Center at Wake Forest University
🇺🇸Winston-Salem, North Carolina, United States
Barrett Cancer Center, The University Hospital
🇺🇸Cincinnati, Ohio, United States
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
University of Pennsylvania Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Simmons Cancer Center - Dallas
🇺🇸Dallas, Texas, United States
Cancer Center at the University of Virginia
🇺🇸Charlottesville, Virginia, United States
Fletcher Allen Health Care - Medical Center Campus
🇺🇸Burlington, Vermont, United States
Tacoma General Hospital
🇺🇸Tacoma, Washington, United States
Rush-Presbyterian-St. Luke's Medical Center
🇺🇸Chicago, Illinois, United States
Holden Comprehensive Cancer Center at The University of Iowa
🇺🇸Iowa City, Iowa, United States
Ellis Fischel Cancer Center - Columbia
🇺🇸Columbia, Missouri, United States
State University of New York Health Science Center at Brooklyn
🇺🇸Brooklyn, New York, United States
Albert B. Chandler Medical Center, University of Kentucky
🇺🇸Lexington, Kentucky, United States
Barbara Ann Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Lineberger Comprehensive Cancer Center, UNC
🇺🇸Chapel Hill, North Carolina, United States
Cancer Center of Albany Medical Center
🇺🇸Albany, New York, United States
University of Oklahoma College of Medicine
🇺🇸Oklahoma City, Oklahoma, United States
Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States