Non-Invasive Measurements of Changes in Pulmonary Artery Pressure in Intensive Care Unit Patients Using Electrical Impedance Tomography - A Feasibility Study (PAP-EIT Study)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Artery Hypertension
- Sponsor
- Insel Gruppe AG, University Hospital Bern
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Mean difference between EIT-derived and PAC-measured changes in pulmonary artery pressure
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
To assess whether changes in electrical impedance - measured using an electrical impedance tomography (EIT) chest belt - can be used to derive changes in pulmonary artery pressure (PAP) in critically ill patients when compared to invasive gold-standard PAP measured using pulmonary artery catheter (PAC).
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Mean difference between EIT-derived and PAC-measured changes in pulmonary artery pressure
Time Frame: Up to 48 hours
The primary outcome is the difference - expressed as mean and standard deviation (SD) - between changes in EIT-derived pulmonary artery pressure (ΔPAP_EIT), derived from changes in the pulmonary pulse arrival time, and changes in pulmonary artery catheter-based pulmonary artery pressure (ΔPAP_PAC). This will be measured over recording periods of up to 48 hours.
Secondary Outcomes
- Data acceptance rate(Up to 48 hours)
- Accuracy and trending ability of EIT-derived cardiac output compared to PAC measurements(Up to 48 hours)
- Concordance rate (%) of directional changes in pulmonary artery pressure between EIT and PAC measurements (Trending ability)(Up to 48 hours)
- Agreement between EIT-derived and ventilator-measured respiratory parameters(Up to 48 hours)