TCTR20210623004
Recruiting
Phase 2
Postoperative hypofractionation and simultaneous integrated boost with or without regional nodal irradiation by TomoTherapy for breast cancer
/A0 sites48 target enrollmentStarted: June 23, 2021Last updated:
Overview
- Phase
- Phase 2
- Status
- Recruiting
- Sponsor
- /A
- Enrollment
- 48
Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 Years to N/A (No limit) (—)
- Sex
- Female
Inclusion Criteria
- •1\. Received breast conserving surgery (BCS)
- •2\. With or without the indication for regional nodal irradiation (RNI)
- •3\. Pathologically confirmed breast cancer
- •4\. Free surgical margins from both invasive carcinoma and ductal carcinoma in situ (DCIS)
- •5\. Indication for tumor bed boost according institutional protocol
- •(age \< 50 years or age \> 50 years with high risk features)
- •6\. Clearly identified primary tumor region preferably by radiopaque clips
- •7\. Surgical wound healing without signs of infection
- •8\. Age 18 years old or more
- •9\. ECOG performance status 0\-1
Exclusion Criteria
- •1\. Patients received mastectomy
- •2\. No indication for boost radiation
- •3\. Inadequate identification of the boost volume
- •4\. Bilateral breast cancer
- •5\. History of prior breast or thoracic radiotherapy
- •6\. Extended postoperative seroma at the beginning of radiotherapy
- •7\. Pregnant or lactating patients
- •8\. Treatment history of other cancer
- •9\. Patients with serious, uncontrolled, physical or cerebrovascular disorders
Investigators
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