Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies
- Conditions
- PreeclampsiaOocyte-donation Pregnancies
- Registration Number
- NCT04731012
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
- Detailed Description
A detailed medical history, questionnaires as well as blood, urine and placental samples will be used to analyse several factors leading to the high risk of preeclampsia in oocyte-donation pregnancies.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 1000
- pregnancy
- severe auto immune disorders
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood. 01.01.2020 - 01.12.2025 T-Cell populations are altered in preeclampsia. HLA-mismatch of mother and donor oocyte lead to a "host-versus-graft" reaction. T-, B- and Natural killer cells are altered in placental tissue of oocyte-donation pregnancies.
- Secondary Outcome Measures
Name Time Method Preeclampsia in oocyte-donation pregnancies is caused by an activation of pro-inflammatory factors and endothelial dysfunction. 01.01.2020 - 01.12.2025 Altered Natural killer cells and B-cells in oocyte-donation pregnancies lead to endothelial dysfunction. Pro-inflammatory factors are higher in OD pregnancy and can be measured in placental tissue via single-cell sequencing.
Trial Locations
- Locations (1)
Experimental and Clinical Research Center (ECRC)
🇩🇪Berlin, Germany