Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Preeclampsia
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 1000
- Locations
- 1
- Primary Endpoint
- Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood.
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
Detailed Description
A detailed medical history, questionnaires as well as blood, urine and placental samples will be used to analyse several factors leading to the high risk of preeclampsia in oocyte-donation pregnancies.
Investigators
Florian Herse
Doctor of Science
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •pregnancy
Exclusion Criteria
- •severe auto immune disorders
Outcomes
Primary Outcomes
Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood.
Time Frame: 01.01.2020 - 01.12.2025
T-Cell populations are altered in preeclampsia. HLA-mismatch of mother and donor oocyte lead to a "host-versus-graft" reaction. T-, B- and Natural killer cells are altered in placental tissue of oocyte-donation pregnancies.
Secondary Outcomes
- Preeclampsia in oocyte-donation pregnancies is caused by an activation of pro-inflammatory factors and endothelial dysfunction.(01.01.2020 - 01.12.2025)