Functional evaluation of donor livers during machine perfusion using indocyanine green (ICG) - for the perspective identification of prognostic factors of transplant functio

Recruiting

• Conditions: K70; K71; K72; K73; K74; K75; K76; K77; C22; Alcoholic liver disease

• Registration Number: DRKS00033469
• Lead Sponsor: niversitätsklinik für Allgemein-, Viszeral-, Gefäß- und Transplantationschirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Terminal liver disease as an indication for transplantation (except HU)
- Tumor diseases as an indication for transplantation

Exclusion Criteria

Chronic renal failure (GFR < 45 ml/min)
- Iodine allergy
- Hyperthyroidism
- Known allergy to ICG

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary study endpoint is to predict liver function via ICG clearance after machine perfusion via an extracorporeal function test of the liver using a procedure already established as a preoperative liver function test.<br>

Secondary Outcome Measures

Name	Time	Method
Further study endpoints, such as postoperative complications (severity > 3 according to Clavien-Dindo classification), 30-day mortality, acute rejection, re-transplantation, EAD, primary non-function (PNF) should be recorded and with the examined parameters from the samples taken can be correlated.