A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

Recruiting

• Conditions: Neovascular Age-related Macular Degeneration; Diabetic Macular Edema; Retinal Vein Occlusion; Branch Retinal Vein Occlusion; Central Retinal Vein Occlusion; Hemi-retinal Vein Occlusion
• Interventions: Drug: Faricimab; Combination Product: Port Delivery System with Ranibizumab

• Registration Number: NCT05476926
• Lead Sponsor: Hoffmann-La Roche

Brief Summary

The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical insights, treatment patterns, and factors driving the treatment decisions among patients being treated with specified Roche ophthalmology products (Faricimab and Port Delivery System with Ranibizumab) in approved retinal indications (neovascular age-related macular degeneration \[nAMD\] and diabetic macular edema \[DME\]) in routine clinical practice. This study will not provide or make recommendations on use of any products including Roche products; treatment decisions will be determined by the treating physician and must be made independently to the decision to participate in this study. Participation in this study will not change or influence a patient's standard of care in any way.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-07-25
• Study First Submitted QC: 2022-07-25
• Study First Posted: 2022-07-27
• Study Start: 2022-11-21
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-02
• Last Update Posted: 2025-05-06
• Primary Completion: 2026-12-31
• Study Completion: 2027-09-13

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

1. Have provided informed consent, as required per local regulations 2.a) Adult patient, as defined by local regulations and local product label, who is newly initiating treatment (or initiated treatment in the previous visit) with a specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye, according to the investigator's discretion in routine clinical practice; OR 2.b) Adult patient, as defined by local regulations and local product label, who is continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye after initiating that treatment in a Roche interventional trial.

Exclusion Criteria

1. Concomitant participation of the patient in an investigational ophthalmology clinical trial that includes receipt of any investigational drug or procedure within the last 28 days prior to enrollment (this restriction does not apply to patients who are rolling over from Roche interventional studies and continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cohort 5: Faricimab for CRVO/HRVO	Faricimab	-
Cohort 3: Port Delivery System with Ranibizumab for nAMD	Port Delivery System with Ranibizumab	-
Cohort 4: Faricimab for BRVO	Faricimab	-
Cohort 1: Faricimab for nAMD	Faricimab	-
Cohort 2: Faricimab for DME	Faricimab	-

Primary Outcome Measures

Name	Time	Method
Change in Visual Acuity from Baseline at 1 Year, per Approved Retinal Indication and Product	Baseline and 1 year	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

Secondary Outcome Measures

Name	Time	Method
Change in Visual Acuity from Baseline Over Time, per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Percentage of Eyes on Each Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other) Over Time, per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Number of Treatments Over Time, per Approved Retinal Indication and Product	At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Cumulative Time Spent on Each Treatment per Eye, Overall and per Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product	From Baseline until end of study (up to 5 years)
Percentage of Eyes with Treatment Switch by Reason for Switch Over Time, per Approved Retinal Indication and Product	At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Percentage of Eyes with Treatment Regimen Switch (Fixed, Treat-and-Extend, As Needed, or Other) by Reason for Switch Over Time, per Approved Retinal Indication and Product	At 3, 6, and 12 months, and annually thereafter (up to 5 years)
Total Number of Visits per Year, per Approved Retinal Indication and Product	Annually (up to 5 years)
Number of Visits With or Without Treatment per Year, per Approved Retinal Indication and Product	Annually (up to 5 years)
Time Interval Between Treatments per Year, per Approved Retinal Indication and Product	Annually (up to 5 years)
Number of Eyes Treated with Ocular Concomitant and Subsequent Medications by Type and Frequency During the Study, per Approved Retinal Indication and Product	From Baseline until end of study (up to 5 years)
Change in Visual Acuity from Baseline Over Time, According to Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Change in Visual Acuity from Baseline Over Time, According to Number of Treatments, per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Change in Visual Acuity from Baseline Over Time, According to Total Number of Visits, per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Change in Visual Acuity from Baseline Over Time, According to Treatment Schedule, per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)	Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.
Change in Central Subfield Thickness (CST) from Baseline Over Time, per Approved Retinal Indication and Product	Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)
Number of Participants with at Least One Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product	From Baseline until end of study (up to 5 years)	Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.
Number of Participants with at Least One Non-Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product	From Baseline until end of study (up to 5 years)	Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.

Trial Locations

Locations (242)

Gifu University Hospital; 🇯🇵 Gifu-shi, Japan

Hiroshima University Hospital; 🇯🇵 Hiroshima, Japan

Sapporo City General Hospital; 🇯🇵 Hokkaido, Japan

Hokkaido University Hospital; 🇯🇵 Hokkaido, Japan

Kobe University Hospital; 🇯🇵 Hyogo, Japan

University of Tsukuba Hospital; 🇯🇵 Ibaraki, Japan

Kozawa eye hospital and diabetes center; 🇯🇵 Ibaraki, Japan

Kagawa University Hospital; 🇯🇵 Kagawa, Japan

Yokohama City University Medical Center; 🇯🇵 Kanagawa, Japan

NHO Tokyo Medical Center; 🇯🇵 Meguro-ku, Japan

Mie University Hospital; 🇯🇵 Mie, Japan

Fukushima Medical University Hospital; 🇯🇵 Miyagi, Japan

Shinshu University Hospital; 🇯🇵 Nagano, Japan

Nagasaki University Hospital; 🇯🇵 Nagasaki, Japan

Japanese Red Cross Nagasaki Genbaku Hospital; 🇯🇵 Nagasaki, Japan

Tazuke-kofukai Medical Research Institute Kitano Hospital; 🇯🇵 Osaka-shi, Japan

Osaka Metropolitan University Hospital; 🇯🇵 Osaka, Japan

Kansai Medical University Hospital; 🇯🇵 Osaka, Japan

Saitama Medical University Hospital; 🇯🇵 Saitama, Japan

Shiga University Of Medical Science Hospital; 🇯🇵 Shiga, Japan

Seirei Hamamatsu General Hospital; 🇯🇵 Shizuoka, Japan

Osaka University Hospital; 🇯🇵 Suita, Japan

Osaka Medical and Pharmaceutical University Hospital; 🇯🇵 Takatsuki-shi, Japan

Tokushima University Hospital; 🇯🇵 Tokushima, Japan

Nihon University Hospital; 🇯🇵 Tokyo, Japan

Juntendo University Hospital; 🇯🇵 Tokyo, Japan

Hospital Dos de Maig; 🇪🇸 Barcelona, Spain

Centre Ophtalmologique d?Imagerie et de Laser; 🇫🇷 Paris, France

CHU Poitiers - Hôpital la Milétrie; 🇫🇷 Poities Cedex, France

Clinique de l'Union; 🇫🇷 Saint-jean, France

Centre St Exupery; 🇫🇷 St Cyr Sur Loire, France

Institut Sourdille; 🇫🇷 St Herblain, France

Chu Toulouse; 🇫🇷 Toulouse, France

Sydney West Retina; 🇦🇺 Westmead, New South Wales, Australia

Rigshospitalet Glostrup; 🇩🇰 Glostrup, Denmark

Retinal Consultants Medical Group; 🇺🇸 Sacramento, California, United States

Retina and Macula Specialists; 🇦🇺 Hurstville, New South Wales, Australia

Retinal Research Institute, LLC; 🇺🇸 Phoenix, Arizona, United States

Retina-Vitreous Associates Medical Group; 🇺🇸 Beverly Hills, California, United States

California Eye Specialists Medical group Inc.; 🇺🇸 Pasadena, California, United States

Advanced Research; 🇺🇸 Coral Springs, Florida, United States

Retina Specialty Institute; 🇺🇸 Pensacola, Florida, United States

University Retina and Macula Associates, PC; 🇺🇸 Lemont, Illinois, United States

Springfield Clinic, Llp; 🇺🇸 Springfield, Illinois, United States

Retina Associates of Kentucky; 🇺🇸 Lexington, Kentucky, United States

Cumberland Valley Retina Consultants PC; 🇺🇸 Hagerstown, Maryland, United States

Associated Retinal Consultants PC; 🇺🇸 Royal Oak, Michigan, United States

Erie Retinal Surgery; 🇺🇸 Erie, Pennsylvania, United States

Palmetto Retina Center; 🇺🇸 Florence, South Carolina, United States

Tennessee Retina PC; 🇺🇸 Nashville, Tennessee, United States

Brown Retina Institute; 🇺🇸 San Antonio, Texas, United States

University of Utah, John Moran Eye Center; 🇺🇸 Salt Lake City, Utah, United States

Piedmont Eye Center; 🇺🇸 Lynchburg, Virginia, United States

Wagner Macula and Retina Center; 🇺🇸 Norfolk, Virginia, United States

Spokane Eye Clinical Research; 🇺🇸 Spokane, Washington, United States

Salud Ocular; 🇦🇷 Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Centro Oftalmologico Dr. Charles S.A.; 🇦🇷 Ciudad Autonoma Buenos Aires, Argentina

Centro Privado de Ojos Romagosa S.A; 🇦🇷 Cordoba, Argentina

CEO Centro de Especialidades Oftalmologicas Tucuman; 🇦🇷 San Miguel de Tucuman, Argentina

Sunshine Coast University Hospital; 🇦🇺 Geebung, Queensland, Australia

Centre For Eye Research Australia; 🇦🇺 East Melbourne, Victoria, Australia

East Melbourne Eye Group; 🇦🇺 East Melbourne, Victoria, Australia

Cabrini Hospital Malvern; 🇦🇺 Malvern, Victoria, Australia

Lions Outback Vision Service in Broome; 🇦🇺 Broome, Western Australia, Australia

The Lions Eye Institute; 🇦🇺 Nedlands, Western Australia, Australia

Medical Center for Eye Health ? Focus Ltd; 🇧🇬 Sofia, Bulgaria

Specialized Eye Hospital Pentagram; 🇧🇬 Sofia, Bulgaria

Eye Clinic St. Petka - Varna; 🇧🇬 Varna, Bulgaria

SHEDAT - Varna EOOD; 🇧🇬 Varna, Bulgaria

Retina Surgical Associates; 🇨🇦 New Westminster, British Columbia, Canada

St Joseph's Centre for Mountain Health Services; 🇨🇦 Hamilton, Ontario, Canada

St. Joseph's Health Care - London; 🇨🇦 London, Ontario, Canada

Retina Institute of Ottawa; 🇨🇦 Ottawa, Ontario, Canada

Toronto Retina Institute; 🇨🇦 Toronto, Ontario, Canada

Clarity eye Institute; 🇨🇦 Vaughan, Ontario, Canada

Institut De L'Oeil Des Laurentides; 🇨🇦 Boisbriand, Quebec, Canada

Clinique d'ophtalmologie et de Retine de l'est; 🇨🇦 Montreal, Quebec, Canada

Eye Health MD (Opthalmology); 🇨🇦 Montreal, Quebec, Canada

Retina MD Clinic; 🇨🇦 Sainte-catherine, Quebec, Canada

Centre Oculaire de Quebec; 🇨🇦 Quebec, Canada

Centro de la Vision; 🇨🇱 Las Condes, Chile

Red Salud UC Christus; 🇨🇱 Metropolitana, Chile

Fundacion Oftalmologica Los Andes; 🇨🇱 Vitacura, Chile

Clinical Hospital Centre Osijek; 🇭🇷 Osijek, Croatia

Clinical Hospital Centre Rijeka; 🇭🇷 Rijeka, Croatia

Special Hospital for Ophthalmology Svjetlost; 🇭🇷 Zagreb, Croatia

CH St Joseph; 🇫🇷 Marseille, Bouches Du Rh(ne, France

CHU Dijon - Hopital Francois Mitterrand; 🇫🇷 Dijon Cedex, Cte-d'Or, France

Groupe Hospitalier Pellegrin; 🇫🇷 Bordeaux, Gironde, France

CHU de Nantes - Hotel Dieu; 🇫🇷 Nantes Cedex 1, Loire Atlantique, France

CHU de St-Etienne - Hopital Nord; 🇫🇷 Saint Etienne, Loire, France

Institut Ophtalmologique De l Ouest Jules Verne; 🇫🇷 Nantes, Paris, France

Centre Hospitalier de la Croix Rousse; 🇫🇷 Lyon Cedex 04, Rhone, France

Hopital Edouard Herriot - CHU Lyon; 🇫🇷 Lyon, Rhone, France

CHU Amiens Picardie, Centre de Recherche Clinique; 🇫🇷 Amiens Cedex 01, Somme, France

Centre Hospitalier de Versailles; 🇫🇷 Le Chesnay Cedex, Yvelines, France

Aix Vision; 🇫🇷 Aix En Provence, France

Clinique des Yeux Bordeaux; 🇫🇷 Bordeaux Floirac, France

Centre Rétine Gallien; 🇫🇷 Bordeaux, France

Centre Hospitalier Intercommunal de Créteil; 🇫🇷 Creteil cedex, France

Clinique du Val d'Ouest- Institut Rhône Alpin; 🇫🇷 Ecully, France

Centre Optha Du Dauphine; 🇫🇷 Grenoble, France

Hôpital Saint-Louis - La Rochelle; 🇫🇷 La Rochelle cedex, France

Visiopole Private Practice; 🇫🇷 Lagord, France

Centre Ophtalmologique Rabelais; 🇫🇷 Lyon, France

Centre Ophtalmologique Kleber; 🇫🇷 Lyon, France

Centre Monticelli Paradis d Ophtalmologie; 🇫🇷 Marseille, France

Clinique de Montargis; 🇫🇷 Montargis, France

Clinique Honore Cave; 🇫🇷 Montauban, France

Alpes Retine; 🇫🇷 Montbonnot-Saint-Martin, France

Centre Des Arceaux; 🇫🇷 Montpellier, France

CHU Nice - Hôpital Saint Roch; 🇫🇷 Nice, France

OPH95; 🇫🇷 Osny, France

Centre Ophtalmologique de L'Odeon; 🇫🇷 Paris, France

Universitaetsklinikum Koeln; 🇩🇪 Koeln, Nordrhein Westfalen, Germany

St. Gertrauden Krankenhaus Berlin, Augenheilkunde; 🇩🇪 Berlin, Germany

Charité Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany

Klinikum Chemnitz gGmbH; 🇩🇪 Chemnitz, Germany

Martin-Luther-Universitaet Halle-Wittenberg - Staedtisches Klinikum Dessau (SKD); 🇩🇪 Dessau - Roßlau, Germany

Universitaetsklinikum Carl Gustav Carus TU Dresden; 🇩🇪 Dresden, Germany

Klinikum der Johann Wolfgang Goethe-Universitaet; 🇩🇪 Frankfurt, Germany

Universitaetsklinikum Frankfurt Goethe-Universitaet; 🇩🇪 Frankfurt, Germany

Universitaetsmedizin Greifswald; 🇩🇪 Greifswald, Germany

Universitaetsklinikum Halle (Saale); 🇩🇪 Halle, Germany

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Germany

Universitaetsklinikum Heidelberg; 🇩🇪 Heidelberg, Germany

Universitaetsklinikum Leipzig; 🇩🇪 Leipzig, Germany

Apotheke am Klinikum Ludwigshafen; 🇩🇪 Ludwigshafen, Germany

Universitaetsklinikum Magdeburg A.oe.R; 🇩🇪 Magdeburg, Germany

Universitätsklinikum Mannheim; 🇩🇪 Mannheim, Germany

Praxis Dr. Amin Gamael; 🇩🇪 Rostock, Germany

Universitaetsaugenklinik Rostock; 🇩🇪 Rostock, Germany

Knappschaftskrankenhaus Sulzbach; 🇩🇪 Sulzbach, Germany

Private Practice of Dr. Astrid Sader Moritz; 🇩🇪 Würzburg, Germany

Grantham Hospital; 🇭🇰 Hong Kong, Hong Kong

Hong Kong Eye Hospital; 🇭🇰 Mongkok, Hong Kong

Rambam Health Care Campus; 🇮🇱 Haifa, Israel

Wolfson Medical Center; 🇮🇱 Holon, Israel

Hadassah; 🇮🇱 Jerusalem, Israel

Meir Medical Center; 🇮🇱 Kfar- Saba, Israel

Rabin MC; 🇮🇱 Petah Tikva, Israel

Tel-Aviv Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel

Azienda Ospedaliero Universitaria Mater Domini; 🇮🇹 Catanzaro, Calabria, Italy

Ospedale Monaldi - AORN dei Colli; 🇮🇹 Napoli, Campania, Italy

Azienda Ospedaliera di Udine Ospedale S. Maria della Misericordia; 🇮🇹 Udine, Friuli-Venezia Giulia, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS; 🇮🇹 Roma, Lazio, Italy

Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien; 🇮🇹 Roma, Lazio, Italy

IRCCS Ospedale Policlinico San Martino; 🇮🇹 Genova, Liguria, Italy

Ospedale San Raffaele; 🇮🇹 Milano, Lombardia, Italy

Azienda Ospedaliera Desio; 🇮🇹 Vimercate, Lombardia, Italy

Ente Ecclesiastico Ospedale Generale Regionale F Miulli; 🇮🇹 Acquaviva Delle Fonti, Piemonte, Italy

Ospedale Oftalmico; 🇮🇹 Torino, Piemonte, Italy

Città della Salute e della Scienza di Torino. Presidio Molinette; 🇮🇹 Torino, Piemonte, Italy

Ospedale Mauriziano Umberto I; 🇮🇹 Torino, Piemonte, Italy

Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari; 🇮🇹 Bari, Puglia, Italy

Ospedale Di Sassuolo; 🇮🇹 Sassuolo, Sardegna, Italy

Azienda Ospedaliera Universitaria "Policlinico - Vittorio Emanuele" (Presidio Gaspare Rodolico); 🇮🇹 Catania, Sicilia, Italy

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone; 🇮🇹 Palermo, Sicilia, Italy

Chukyo Hospital; 🇯🇵 Aichi, Japan

Nagoya City University Hospital; 🇯🇵 Aichi, Japan

Aichi Medical University Hospital; 🇯🇵 Aichi, Japan

Akita University Hospital; 🇯🇵 Akita-shi, Japan

Chiba University Hospital; 🇯🇵 Chiba, Japan

Juntendo University Urayasu Hospital; 🇯🇵 Chiba, Japan

Toho University Sakura Medical Center; 🇯🇵 Chiba, Japan

University of Yamanashi Hospital; 🇯🇵 Chuo-shi, Japan

Kyushu University Hospital; 🇯🇵 Fukuoka, Japan

Kurume University Hospital; 🇯🇵 Fukuoka, Japan

Keio University Hospital; 🇯🇵 Tokyo, Japan

Tokyo Women's Medical University Hospital; 🇯🇵 Tokyo, Japan

Kyorin University Hospital; 🇯🇵 Tokyo, Japan

Fujita Health University Hospital; 🇯🇵 Toyoake-shi, Japan

Yamagata University Hospital; 🇯🇵 Yamagata, Japan

Yamaguchi University Hospital; 🇯🇵 Yamaguchi, Japan

University of Fukui Hospital; 🇯🇵 Yoshida-gun, Japan

Emanuelli Research and Development Center; 🇵🇷 Arecibo, Puerto Rico

National University Hospital; 🇸🇬 Singapore, Singapore

Singapore National Eye Centre; 🇸🇬 Singapore, Singapore

Eye & Retina Surgeons; 🇸🇬 Singapore, Singapore

Tan Tock Seng Hospital; 🇸🇬 Singapore, Singapore

Eagle Eye Centre; 🇸🇬 Singapore, Singapore

Fundacio Privada Hospital Asil de Granollers; 🇪🇸 Granollers, Barcelona, Spain

Hospital Universitari de Bellvitge; 🇪🇸 L' Hospitalet DE Llobregat, Barcelona, Spain

Hospital Universitari Son Espases; 🇪🇸 Palma de Mallorca, Islas Baleares, Spain

Complejo Hospitalario Universitario de Ferrol; 🇪🇸 Ferrol, LA Coruna, Spain

Complejo Hospitalario Universitario de Santiago.; 🇪🇸 Santiago de Compostela, LA Coruna, Spain

Complejo Hospitalario San Millán y San Pedro De La Rioja; 🇪🇸 Logroño, LA Rioja, Spain

Hospital Universitario Insular de Gran Canaria; 🇪🇸 Las Palmas de Gran Canaria, LAS Palmas, Spain

Hospital Costa del Sol; 🇪🇸 Marbella, Malaga, Spain

Hospital Xeral-Cies de Vigo; 🇪🇸 Vigo, Pontevedra, Spain

Hospital Universitario Nuestra Señora de la Candelaria; 🇪🇸 Santa Cruz de Tenerife, Tenerife, Spain

Hospital de Basurto; 🇪🇸 Bilbao, Vizcaya, Spain

Complejo Hospitalario Universitario de Albacete; 🇪🇸 Albacete, Spain

Hospital de la Santa Creu i Sant Pau; 🇪🇸 Barcelona, Spain

Hospital Universitari Vall dHebron (CEMCAT); 🇪🇸 Barcelona, Spain

Hospital Clinic de Barcelona; 🇪🇸 Barcelona, Spain

Complejo Asistencial Universitario de Burgos; 🇪🇸 Burgos, Spain

Hospital Universitario Puerta del Mar; 🇪🇸 Cadiz, Spain

Hospital Universitario Reina Sofia; 🇪🇸 Cordoba, Spain

Hospital Universitario Virgen de Las Nieves; 🇪🇸 Granada, Spain

Hospital Carlos Haya; 🇪🇸 Malaga, Spain

Hospital Universitario Virgen de La Arrixaca; 🇪🇸 Murcia, Spain

Hospital Universitario Virgen Del Rocio Sevila; 🇪🇸 Sevilla, Spain

Hospital Universitario Rio Hortega; 🇪🇸 Valladolid, Spain

Hospital Universitario Miguel Servet; 🇪🇸 Zaragoza, Spain

Kantonsspital Aarau AG; 🇨🇭 Aarau, Switzerland

Inselspital-Universitaetsspital Bern; 🇨🇭 Bern, Switzerland

Vista Augenklinik Binningen; 🇨🇭 Binningen, Switzerland

Hôpital ophtalmique Jules-Gonin; 🇨🇭 Lausanne, Switzerland

Swiss Visio Montchoisi; 🇨🇭 Lausanne, Switzerland

Ospedale Regionale di Lugano; 🇨🇭 Lugano, Switzerland

Luzerner Kantonsspital Luzern; 🇨🇭 Luzern, Switzerland

Stadtspital Triemli; 🇨🇭 Zürich, Switzerland

Burjeel Hopital; 🇦🇪 Abu dhabi, United Arab Emirates

Medcare Eye Center - Dubai; 🇦🇪 Dubai, United Arab Emirates

Bedford Hospital; 🇬🇧 Bedford, United Kingdom

Mater Infirmorum Hospital; 🇬🇧 Belfast, United Kingdom

Birmingham Midland Eye Centre; 🇬🇧 Birmingham, United Kingdom

Bradford Royal Infirmary; 🇬🇧 Bradford, United Kingdom

Bristol Eye Hospital; 🇬🇧 Bristol, United Kingdom

University Hospital of Wales; 🇬🇧 Cardiff, United Kingdom

Cheltenham General Hospital; 🇬🇧 Cheltenham, United Kingdom

Essex County Hospital; 🇬🇧 Colchester, United Kingdom

University Hospitals Coventry and Warwickshire NHS Trust; 🇬🇧 Coventry, United Kingdom

Frimley Park Hospital; 🇬🇧 Frimley, United Kingdom

North West London Hospitals NHS Trust; 🇬🇧 Harrow, United Kingdom

Hull Royal Infirmary; 🇬🇧 Hull, United Kingdom

St James University Hospital; 🇬🇧 Leeds, United Kingdom

Royal Liverpool University Hospital; 🇬🇧 Liverpool, United Kingdom

Moorfields Eye Hospital; 🇬🇧 London, United Kingdom

Royal Free Hospital; 🇬🇧 London, United Kingdom

Kings College Hospital; 🇬🇧 London, United Kingdom

Maidstone Hospital; 🇬🇧 Maidstone, Kent, United Kingdom

Manchester Royal Eye Hospital; 🇬🇧 Manchester, United Kingdom

Royal Victoria Infirmary; 🇬🇧 Newcastle upon Tyne, United Kingdom

James Paget University Hospitals NHS Foundation Trust; 🇬🇧 Norfolk, United Kingdom

John Radcliffe Hospital; 🇬🇧 Oxford, United Kingdom

Royal Hallamshire Hospital; 🇬🇧 Sheffield, United Kingdom

Southampton General Hospital; 🇬🇧 Southampton, United Kingdom

Sunderland Eye Infirmary; 🇬🇧 Sunderland, United Kingdom

Torbay Hospital; 🇬🇧 Torquay, United Kingdom

The Royal Wolverhampton Hospitals NHS Trust; 🇬🇧 Wolverhampton, United Kingdom